PTGS2

Gene Symbol	PTGS2
Entrez Gene	5743
Alt Symbol	COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Species	Human
Gene Type	protein-coding
Description	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Other Description	PGH synthase 2|PHS II|cyclooxygenase 2b|prostaglandin G/H synthase 2|prostaglandin H2 synthase 2
Swissprots	Q16876 P35354 A8K802
Accessions	AAA57317 AAD14842 AAF85977 AAN87129 AAO38056 AAQ75702 BAA05698 CBH19826 CBX54355 EAW91216 P35354 AJ634912 CAG25548 AK292167 BAF84856 AY151286 AAN52932 AY462100 AAR23927 BC013734 AAH13734 BM978796 DA277667 EU176282 ABW03733 EU176597 ABW03398 HM473188 ADJ56342 L15326 AAA35803 M90100 AAA58433 NM_000963 NP_000954
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. {ECO:0000269|PubMed:16373578}.
Subcellular Location	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways	Leishmaniasis, Chemical carcinogenesis, Retrograde endocannabinoid signaling, TNF signaling pathway, Ovarian steroidogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PTGS2 gene - orb92805 from Biorbyt Prices $306.00 Sizes 10 μg Species Human

Human-PTGS2-cDNA-Clone - DC03678 from Abgent, a WuXi AppTec company Prices $815.40 Sizes 10 µg Species Human Accession BC013734

PTGS2 - MBS1273890 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC013734

Human COX-2/PTGS2 Gene ORF cDNA clone in cloning vector - HG12036-G from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12036-NY from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12036-NF from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG12036-ANR from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, N-His tag - HG12036-NH from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12036-CF from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12036-NM from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12036-CM from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, C-His tag - HG12036-CH from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12036-ACG from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid - HG12036-UT from Sino Biological Species Human

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12036-CY from Sino Biological Species Human

Human PTGS2 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG12036-G-N from Sino Biological Species Human Accession NM_000963

Human COX-2/PTGS2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12036-ANG from Sino Biological Species Human

Human PTGS2 ORF Clone (BC013734) - CDCS406020 from Creative biogene Species Human Accession P35354

Human PTGS2 ORF clone (NM_000963) - CDCB160295 from Creative biogene Species Human

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