PTGS2

Gene Symbol	PTGS2
Entrez Gene	5743
Alt Symbol	COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Species	Human
Gene Type	protein-coding
Description	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Other Description	PGH synthase 2|PHS II|cyclooxygenase 2b|prostaglandin G/H synthase 2|prostaglandin H2 synthase 2
Swissprots	Q16876 P35354 A8K802
Accessions	AAA57317 AAD14842 AAF85977 AAN87129 AAO38056 AAQ75702 BAA05698 CBH19826 CBX54355 EAW91216 P35354 AJ634912 CAG25548 AK292167 BAF84856 AY151286 AAN52932 AY462100 AAR23927 BC013734 AAH13734 BM978796 DA277667 EU176282 ABW03733 EU176597 ABW03398 HM473188 ADJ56342 L15326 AAA35803 M90100 AAA58433 NM_000963 NP_000954
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. {ECO:0000269|PubMed:16373578}.
Subcellular Location	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways	Leishmaniasis, Chemical carcinogenesis, Retrograde endocannabinoid signaling, TNF signaling pathway, Ovarian steroidogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human COX2 / Cyclooxygenase 2 full length protein - ab58868 from Abcam Category Protein Prices $408.00 Sizes 500 units Source Baculovirus infected Sf21 cells Species Human

Human COX2 / Cyclooxygenase 2 full length protein - ab159279 from Abcam Category Protein Source Wheat germ Species Human

Human COX2 / Cyclooxygenase 2 full length protein - ab159280 from Abcam Category Protein Source Wheat germ Species Human

Human COX2 / Cyclooxygenase 2 full length protein - ab198646 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human COX2 / Cyclooxygenase 2 peptide - ab23276 from Abcam Category Peptide Species Human

Sheep COX2 / Cyclooxygenase 2 full length protein - ab81696 from Abcam Category Protein Source Native Species Sheep

PTGS2 / COX2 / COX-2 Antibody Blocking Peptide - LS-E1063 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTGS2 / COX2 / COX-2 Antibody Blocking Peptide - LS-E25287 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human COX-2 Protein - H00005743-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

COX-2 Recombinant Protein - H00005743-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PTGS2-Antibody-Center-P378-Blocking-peptide - BP11553c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTGS2-Antibody-Center-H193-Blocking-peptide - BP14091c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

COX2 blocking peptide - GTX15839-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Pig, Bovine

Recombinant human Prostaglandin G/H synthase 2 (OPCA00192) - OPCA00192 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human Cox2 protein - orb244470 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

COX-2 peptide - orb72561 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Goat anti PTGS2 antibody Immunizing peptide - orb17615 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Cox 2 Blocking Peptide - 33R-10476 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

PGHS-2 Blocking Peptide - abx063163 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig, Sheep

COX2 / Cyclooxygenase 2 Peptide - AC21-0115-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Cyclooxygenase 2 - H00005743-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cyclooxygenase 2 - H00005743-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cyclooxygenase 2 - H00005743-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Cyclooxygenase 2 Control Peptide - AP00118CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

COX-2 Cyclooxygenase-2 (COX-2), human - 12-7811-A from ARP American Research Products Category Protein Prices $259.00 Sizes 1 ku Source Recombinant COX-2 isolated from a Baculovirus Expression System in Sf21 cells Species Human

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