ERI1

Gene Symbol ERI1
Entrez Gene 90459
Alt Symbol 3'HEXO, HEXO, THEX1
Species Human
Gene Type protein-coding
Description exoribonuclease 1
Other Description 3' exoribonuclease|3'-5' exonuclease ERI1|3'-5' exoribonuclease 1|Eri-1 homolog|enhanced RNAi three prime mRNA exonuclease homolog 1|histone mRNA 3' end-specific exonuclease|histone mRNA 3'-end-specific exoribonuclease|histone mRNA 3'-exonuclease 1|protein 3'hExo|three prime histone mRNA exonuclease 1|three prime mRNA exonuclease 1
Swissprots A8K4U7 Q8IV48 Q9NSX3
Accessions EAW65568 EAW65569 EAW65570 Q8IV48 AK024646 AK226180 AK291062 BAF83751 AK301506 BAG63016 AL137679 CAB70871 AV709794 AY310909 AAQ21219 BC035279 AAH35279 DQ890841 ABM81767 DQ893996 ABM84922 XM_005272401 XP_005272458 XM_011543848 XP_011542150 XM_011543849 XP_011542151 XM_011543850 XP_011542152 XM_011543851 XP_011542153 NM_153332 NP_699163
Function RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. {ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:16912046}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16912046}. Nucleus {ECO:0000269|PubMed:16912046}. Nucleus, nucleolus {ECO:0000269|PubMed:16912046}.

THEX1 Antibody - 4049 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using THEX1 Antibody.

THEX1 (D2B4) Rabbit mAb - 4052 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2B4
Western blot analysis of extracts from various cell types using THEX1 (D2B4) Rabbit mAb.

THEX1 (D66A11) Rabbit mAb - 4055 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D66A11
Western blot analysis of extracts from various cell lines using THEX1 (D66A11) Rabbit mAb.

ERI-1 (B-10) - sc-137089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERI-1 (B-10): sc-137089. Western blot analysis of ERI-1 expression in non-transfected 293T: sc-117752 (A), human ERI-1 transfected 293T: sc-114320 (B), JAR (C) and HeLa (D) whole cell lysates.

ERI-1 (C-8) - sc-137099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERI-1 (C-8): sc-137099. Western blot analysis of ERI-1 expression in non-transfected 293T: sc-117752 (A), human ERI-1 transfected 293T: sc-114320 (B), JAR (C) and HeLa (D) whole cell lysates.

ERI-1 (F-15) - sc-34609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ERI-1 (F-15): sc-34609. Western blot analysis of ERI-1 expression in non-transfected: sc-117752 (A) and human ERI-1 transfected: sc-114320 (B) 293T whole cell lysates.

ERI-1 (H-135) - sc-66881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ERI-1 (H-135): sc-66881. Western blot analysis of ERI-1 expression in non-transfected: sc-117752 (A) and human ERI-1 transfected: sc-114320 (B) 293T whole cell lysates.

ERI-1 (L-13) - sc-34611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ERI-1 (I-15) - sc-34610 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ERI-1 (I-15): sc-34610. Western blot analysis of ERI-1 expression in NIH/3T3 whole cell lysate.

Anti-HEXO antibody - ab93385 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HEXO antibody (ab93385) at 1/1000 dilutionLane 1 : Rat brain lysateLane 2 : Rat brain lysateLysates/proteins at 84 µg per lane.

Anti-HEXO antibody - ab129601 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-HEXO antibody (ab129601) at 1/100 dilution + 293 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-HEXO antibody - ab173394 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-HEXO antibody (ab173394) at 1/500 dilutionLane 1 : HEXO transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG at 1/2500 dilution

Anti-HEXO antibody [1B3] - ab119413 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B3
Immunohistochemical staining of paraffin-embedded Human tonsil using 1/150 ab119413.

Anti-ERI1 / HEXO Antibody (aa231-280) - LS-C30834 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
B: HepG2 Cell Lysate

Anti-ERI1 / HEXO Antibody - LS-C137433 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (aa79-109, Biotin) - LS-C256790 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (aa79-109, AP) - LS-C256788 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (aa79-109, APC) - LS-C256789 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (Asp298) - LS-C193202 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (aa79-109, Azide-free, HRP) - LS-C256792 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (aa79-109, FITC) - LS-C256791 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (aa80-109) - LS-C167808 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ERI1 Antibody western blot of 293 cell line lysates (35 ug/lane). The ERI1 antibody detected the ERI1 protein (arrow).

Anti-ERI1 / HEXO Antibody (aa29-78) - LS-C80401 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCF7 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-ERI1 / HEXO Antibody (aa79-109, PE) - LS-C256795 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERI1 / HEXO Antibody (aa249-298) - LS-C291937 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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