| Gene Symbol |
ERI1
|
| Entrez Gene |
90459
|
| Alt Symbol |
3'HEXO, HEXO, THEX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exoribonuclease 1
|
| Other Description |
3' exoribonuclease|3'-5' exonuclease ERI1|3'-5' exoribonuclease 1|Eri-1 homolog|enhanced RNAi three prime mRNA exonuclease homolog 1|histone mRNA 3' end-specific exonuclease|histone mRNA 3'-end-specific exoribonuclease|histone mRNA 3'-exonuclease 1|protein 3'hExo|three prime histone mRNA exonuclease 1|three prime mRNA exonuclease 1
|
| Swissprots |
A8K4U7 Q8IV48 Q9NSX3
|
| Accessions |
EAW65568 EAW65569 EAW65570 Q8IV48 AK024646 AK226180 AK291062 BAF83751 AK301506 BAG63016 AL137679 CAB70871 AV709794 AY310909 AAQ21219 BC035279 AAH35279 DQ890841 ABM81767 DQ893996 ABM84922 XM_005272401 XP_005272458 XM_011543848 XP_011542150 XM_011543849 XP_011542151 XM_011543850 XP_011542152 XM_011543851 XP_011542153 NM_153332 NP_699163
|
| Function |
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. {ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:16912046}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16912046}. Nucleus {ECO:0000269|PubMed:16912046}. Nucleus, nucleolus {ECO:0000269|PubMed:16912046}.
|