ERI1

Gene Symbol	ERI1
Entrez Gene	90459
Alt Symbol	3'HEXO, HEXO, THEX1
Species	Human
Gene Type	protein-coding
Description	exoribonuclease 1
Other Description	3' exoribonuclease|3'-5' exonuclease ERI1|3'-5' exoribonuclease 1|Eri-1 homolog|enhanced RNAi three prime mRNA exonuclease homolog 1|histone mRNA 3' end-specific exonuclease|histone mRNA 3'-end-specific exoribonuclease|histone mRNA 3'-exonuclease 1|protein 3'hExo|three prime histone mRNA exonuclease 1|three prime mRNA exonuclease 1
Swissprots	A8K4U7 Q8IV48 Q9NSX3
Accessions	EAW65568 EAW65569 EAW65570 Q8IV48 AK024646 AK226180 AK291062 BAF83751 AK301506 BAG63016 AL137679 CAB70871 AV709794 AY310909 AAQ21219 BC035279 AAH35279 DQ890841 ABM81767 DQ893996 ABM84922 XM_005272401 XP_005272458 XM_011543848 XP_011542150 XM_011543849 XP_011542151 XM_011543850 XP_011542152 XM_011543851 XP_011542153 NM_153332 NP_699163
Function	RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. {ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:16912046}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16912046}. Nucleus {ECO:0000269|PubMed:16912046}. Nucleus, nucleolus {ECO:0000269|PubMed:16912046}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HEXO full length protein - ab132251 from Abcam Category Protein Source Wheat germ Species Human

Human HEXO peptide - ab50554 from Abcam Category Peptide Species Human

ERI1 / HEXO Antibody Blocking Peptide - LS-E4244 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERI1 / HEXO Antibody Blocking Peptide - LS-E15120 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERI1 / HEXO Antibody Blocking Peptide - LS-E15119 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HEXO Protein - H00090459-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERI1-Antibody-N-term-Blocking-Peptide - BP16515a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ERI1 blocking peptide - GTX89737-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

THEX1 Blocking Peptide - 33R-2641 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

THEX1 Blocking Peptide - 33R-3597 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ERI1 / THEX1 - H00090459-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ERI1 / THEX1 - H00090459-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ERI1 fusion protein - Ag6125 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human ERI1, His-tagged - ERI1-12535H from Creative Biomart Category Protein Source E.coli Species Human

ERI1 (D298) Peptide - BS9202P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

ERI1 / THEX1 - TP306777 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Exoribonuclease 1 (ERI1) - RPD162Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Exoribonuclease 1 (ERI1) - RPD162Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

HEXO Recombinant Protein Antigen - NBP2-38782PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HEXO Recombinant Protein Antigen - NBP2-38756PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ERI1 Peptide, Human - M34GP05049H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Exoribonuclease 1 (ERI1) - RPU50658 from Biomatik Category Protein Prices $182.00, $315.00, $482.00, $602.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

ERI1 Recombinant Protein (OPCD00383) - OPCD00383 from Aviva Systems Biology Category Protein Source E.coli Species Human

Exoribonuclease 1, Recombinant Protein - MBS2034459 from MyBioSource Category Protein Prices $160.00, $320.00, $495.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic Expression Species Human

Exoribonuclease 1, Recombinant Protein - MBS2034118 from MyBioSource Category Protein Prices $170.00, $345.00, $535.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic Expression Species Mouse

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