ERI1
| Gene Symbol | ERI1 |
|---|---|
| Entrez Gene | 90459 |
| Alt Symbol | 3'HEXO, HEXO, THEX1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | exoribonuclease 1 |
| Other Description | 3' exoribonuclease|3'-5' exonuclease ERI1|3'-5' exoribonuclease 1|Eri-1 homolog|enhanced RNAi three prime mRNA exonuclease homolog 1|histone mRNA 3' end-specific exonuclease|histone mRNA 3'-end-specific exoribonuclease|histone mRNA 3'-exonuclease 1|protein 3'hExo|three prime histone mRNA exonuclease 1|three prime mRNA exonuclease 1 |
| Swissprots | A8K4U7 Q8IV48 Q9NSX3 |
| Accessions | EAW65568 EAW65569 EAW65570 Q8IV48 AK024646 AK226180 AK291062 BAF83751 AK301506 BAG63016 AL137679 CAB70871 AV709794 AY310909 AAQ21219 BC035279 AAH35279 DQ890841 ABM81767 DQ893996 ABM84922 XM_005272401 XP_005272458 XM_011543848 XP_011542150 XM_011543849 XP_011542151 XM_011543850 XP_011542152 XM_011543851 XP_011542153 NM_153332 NP_699163 |
| Function | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. {ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:16912046}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16912046}. Nucleus {ECO:0000269|PubMed:16912046}. Nucleus, nucleolus {ECO:0000269|PubMed:16912046}. |
ERI-1 CRISPR/Cas9 KO Plasmid (h) - sc-408995 from Santa Cruz Biotechnology
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ERI-1 HDR Plasmid (h) - sc-408995-HDR from Santa Cruz Biotechnology
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ERI-1 Double Nickase Plasmid (h) - sc-408995-NIC from Santa Cruz Biotechnology
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ERI-1 Double Nickase Plasmid (h2) - sc-408995-NIC-2 from Santa Cruz Biotechnology
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ERI-1 CRISPR Activation Plasmid (h) - sc-408995-ACT from Santa Cruz Biotechnology
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ERI-1 CRISPR Activation Plasmid (h2) - sc-408995-ACT-2 from Santa Cruz Biotechnology
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ERI-1 Lentiviral Activation Particles (h) - sc-408995-LAC from Santa Cruz Biotechnology
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ERI-1 Lentiviral Activation Particles (h2) - sc-408995-LAC-2 from Santa Cruz Biotechnology
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ERI-1 siRNA (h) - sc-45559 from Santa Cruz Biotechnology
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ERI-1 shRNA Plasmid (h) - sc-45559-SH from Santa Cruz Biotechnology
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ERI-1 shRNA (h) Lentiviral Particles - sc-45559-V from Santa Cruz Biotechnology
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HEXO RNAi - H00090459-R01 from Novus Biologicals
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MISSION® esiRNA - EHU070481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7963 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7963 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07659 from Sigma-Aldrich
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ERI1 siRNA (Human) - CRJ3949 from Cohesion Biosciences
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ERI1 - MBS8236259 from MyBioSource
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shRNA set against Human ERI1 (NM_153332.3) - SHH287061 from Creative biogene
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shRNA set against Human THEX1(NM_153332.3) - SHL069002 from Creative biogene
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Human ERI1 siRNA - orb274450 from Biorbyt
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ERI1 shRNA Plasmid (Human) - CHJ3949 from Cohesion Biosciences
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ERI1 miRNA 3'UTR clone - MiUTR1H-10378 from Creative biogene
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