CAMK4

Gene Symbol	CAMK4
Entrez Gene	814
Alt Symbol	CaMK IV, CaMK-GR, IV, caMK
Species	Human
Gene Type	protein-coding
Description	calcium/calmodulin-dependent protein kinase IV
Other Description	CAM kinase IV|CAM kinase- GR|brain Ca(2+)-calmodulin-dependent protein kinase type IV|brain Ca++-calmodulin-dependent protein kinase type IV|caM kinase-GR|calcium/calmodulin-dependent protein kinase type IV|calcium/calmodulin-dependent protein kinase type IV catalytic chain
Swissprots	Q16566 D3DSZ7
Accessions	EAW49032 EAW49033 EAW49034 Q16566 AK311662 AK312840 BAG35694 AL833368 BC016695 AAH16695 BC025687 AAH25687 BG721313 D30742 BAA06403 DA396146 DQ892902 ABM83828 DQ893195 ABM84121 DQ893196 ABM84122 DQ896523 ABM87522 DQ896524 ABM87523 DQ896525 ABM87524 DQ896526 ABM87525 L17000 AAA35639 L24959 AAA18251 XR_948301 XR_948302 XR_948303 NM_001744 NP_001735
Function	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA
Subcellular Location	Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. {ECO:0000269|PubMed:12065094, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8397199}.
Top Pathways	cAMP signaling pathway, Long-term potentiation, Oxytocin signaling pathway, Alcoholism, Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-CAMK4 / CaMK IV (Thr196/200) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1324 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat CAMK4 / CaMK IV ELISA Kit (Cell-Based ELISA) - LS-F1848 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), Human, ELISA Kit - E01C1340 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Calcium/calmodulin-dependent protein kinase-_ (CAMK 2), Human, ELISA Kit - CSB-E17312h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Collagen alpha-1 (IV) chain (COL4A1), Human, ELISA Kit - E01C1909 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/ml

Collagen alpha-2 (IV) chain (COL4A2), Human, ELISA Kit - E01C1910 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/ml

Collagen alpha-3 (IV) chain (COL4A3), Human, ELISA Kit - E01C1911 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/ml

Collagen alpha-4 (IV) chain (COL4A4), Human, ELISA Kit - E01C1913 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/ml

Collagen alpha-5 (IV) chain (COL4A5), Human, ELISA Kit - E01C1914 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/ml

Collagen alpha-6 (IV) chain (COL4A6), Human, ELISA Kit - E01C1915 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/ml

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7247374 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7234602 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7229299 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7221378 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7249541 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7226267 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7247776 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7211175 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7226797 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7235565 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Calcium/calmodulin-dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7224817 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

CaMK4 Colorimetric Cell-Based ELISA Kit - CB5094 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

CaMK4 (Phospho-Thr196/200) Colorimetric Cell-Based ELISA Kit - CBP1329 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Calcium/calmodulin dependent protein kinase type IV (CAMK4), ELISA Kit - MBS7230332 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

calcium/calmodulin-dependent protein kinase IV, ELISA Kit - MBS9327047 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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