| Gene Symbol | CAMK4 |
|---|---|
| Entrez Gene | 814 |
| Alt Symbol | CaMK IV, CaMK-GR, IV, caMK |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase IV |
| Other Description | CAM kinase IV|CAM kinase- GR|brain Ca(2+)-calmodulin-dependent protein kinase type IV|brain Ca++-calmodulin-dependent protein kinase type IV|caM kinase-GR|calcium/calmodulin-dependent protein kinase type IV|calcium/calmodulin-dependent protein kinase type IV catalytic chain |
| Swissprots | Q16566 D3DSZ7 |
| Accessions | EAW49032 EAW49033 EAW49034 Q16566 AK311662 AK312840 BAG35694 AL833368 BC016695 AAH16695 BC025687 AAH25687 BG721313 D30742 BAA06403 DA396146 DQ892902 ABM83828 DQ893195 ABM84121 DQ893196 ABM84122 DQ896523 ABM87522 DQ896524 ABM87523 DQ896525 ABM87524 DQ896526 ABM87525 L17000 AAA35639 L24959 AAA18251 XR_948301 XR_948302 XR_948303 NM_001744 NP_001735 |
| Function | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA |
| Subcellular Location | Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. {ECO:0000269|PubMed:12065094, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8397199}. |
| Top Pathways | cAMP signaling pathway, Long-term potentiation, Oxytocin signaling pathway, Alcoholism, Amphetamine addiction |