CAMK4

Gene Symbol CAMK4
Entrez Gene 814
Alt Symbol CaMK IV, CaMK-GR, IV, caMK
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent protein kinase IV
Other Description CAM kinase IV|CAM kinase- GR|brain Ca(2+)-calmodulin-dependent protein kinase type IV|brain Ca++-calmodulin-dependent protein kinase type IV|caM kinase-GR|calcium/calmodulin-dependent protein kinase type IV|calcium/calmodulin-dependent protein kinase type IV catalytic chain
Swissprots Q16566 D3DSZ7
Accessions EAW49032 EAW49033 EAW49034 Q16566 AK311662 AK312840 BAG35694 AL833368 BC016695 AAH16695 BC025687 AAH25687 BG721313 D30742 BAA06403 DA396146 DQ892902 ABM83828 DQ893195 ABM84121 DQ893196 ABM84122 DQ896523 ABM87522 DQ896524 ABM87523 DQ896525 ABM87524 DQ896526 ABM87525 L17000 AAA35639 L24959 AAA18251 XR_948301 XR_948302 XR_948303 NM_001744 NP_001735
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA
Subcellular Location Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. {ECO:0000269|PubMed:12065094, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8397199}.
Top Pathways cAMP signaling pathway, Long-term potentiation, Oxytocin signaling pathway, Alcoholism, Amphetamine addiction

CaMKIV Antibody - 4032 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human Jurkat cells (lane1), rat brain (lane 2) and mouse brain (lane 3), using CaMKIV Antibody.

CaMKIV (A-3) - sc-166156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIV (A-3): sc-166156. Western blot analysis of CaMKIV expression in 293T whole cell lysate.

CaMKIV (B-5) - sc-166157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIV (B-5): sc-166157. Western blot analysis of CaMKIV expression in non-transfected: sc-117752 (A) and human CaMKIV transfected: sc-114186 (B) 293T whole cell lysates.

CaMKIV (C-20) - sc-1545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CaMKIV (C-20): sc-1545. Western blot analysis of CaMKIV expression in A-431 (A), HeLa (B), Jurkat (C) and CCRF-HSB-2 (D) whole cell lysates.

CaMKIV (C-7) - sc-17762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIV (C-7): sc-17762. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing nuclear staining of cells in granular and molecular layers. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

CaMKIV (H-146) - sc-9036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CaMKIV (H-146): sc-9036. Indirect, intracellular FCM analysis of fixed and permeabilized Jurkat cells stained with CaMKIV (H-146), followed by PE-conjugated goat anti-rabbit IgG: sc-3739. Black line histogram represents the isotype control, normal rabbit IgG: sc-3888.

CaMKIV (H-5) - sc-55501 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIV (H-5): sc-55501. Western blot analysis of CaMKIV expression in Jurkat whole cell lysate.

CaMKIV (26) - sc-136249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CaMKIV (26): sc-136249. Western blot analysis of CaMKIV expression in non-transfected: sc-110760 (A) and human CaMKIV transfected: sc-158335 (B) 293 whole cell lysates.

Anti-CAMKIV (phospho T196 + T200) antibody - ab59424 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab59424, at a 1/50 dilution, staining paraffin embedded human brain tissue sections by Immunohistochemistry in the absence (left image) or presence (right image) of the phosphopeptide.

Anti-CAMKIV (phospho T200) antibody - ab195000 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMKIV (phospho T200) antibody (ab195000) at 1/500 dilutionLane 1 : Hydrogen peroxide K562 cell extractLane 2 : Hydrogen peroxide K562 cell extract with antigen-specific peptide

Anti-CAMKIV antibody - ab3557 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CAMKIV antibody - ab189185 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human thymus tissue labeling CAMKIV with ab189185 at 10 µg/ml.

Anti-CAMKIV antibody - ab34868 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMKIV antibody (ab34868) at 1/1000 dilution (for 2 hours at room temperature)Lane 1 : Rat brain lysateLane 2 : Jurkat cell lysateLane 3 : Rat brain lysate with Immunizing peptideLane 4 : Jurkat cells lysate with Immunizing peptideLysates/proteins at 35 µg per lane.SecondaryIRDye TM800 conjugated Gt-a-Rabbit IgG for 45 min at room temperature at 1/10000 dilution

Anti-CAMKIV antibody - ab70229 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling CAMKIV with ab70229 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-CAMKIV antibody - ab88544 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-CAMKIV antibody (ab88544) at 1 µg/ml + Jurkat cell lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-CAMKIV antibody - ab37997 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMKIV antibody (ab37997) at 1/100 dilutionLane 1 : Ramos cell lysate Lane 2 : Mouse cerebellum tissue lysate SecondaryHRP-anti-rabbit

Anti-CAMKIV antibody - ab59386 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human brain tissue using ab59386 at a 1/50 dilution.Left image un-treated.Right image treated with peptide.

Anti-CAMKIV antibody - ab84294 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84294, at 1/250 dilution, staining CAMKIV in formalin-fixed, paraffin-embedded human ovarian tumor tissue by Immunohistochemistry using DAB detection.

Anti-CAMKIV antibody [1A3] - ab124279 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1A3
ab124279, at 5 µg/ml, staining CAMKIV in formalin fixed, paraffin embedded Human tonsil tissue by Imunohistochemistry.

Anti-CAMKIV antibody [3E5.E8] - ab184684 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 3E5.E8
All lanes : Anti-CAMKIV antibody [3E5.E8] (ab184684) at 1/200 dilutionLane 1 : Mouse brain lysateLane 2 : Mouse brain lysate + CIPLane 3 : CaMKIV overexpression lysateLane 4 : CaMKIV overexpression lysate + CIPLane 5 : Jurkat cell lysate

Anti-CAMKIV antibody [8C5B8] - ab140670 from Abcam

Host Mouse
Clonality Monoclonal
Clone 8C5B8
Immunofluorescent analysis of HepG2 cells labelling CAMKIV with ab140670 at 1/200 dilution (green); Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Anti-CAMKIV antibody [EP2564Y] - ab75874 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2564Y
All lanes : Anti-CAMKIV antibody [EP2564Y] (ab75874) at 1/2000 dilutionLane 1 : Jurkat cell lysateLane 2 : Human brain lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/1000 dilution

Anti-CAMKIV antibody [EP2565AY] - ab68218 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2565AY
ab68218 stained HeLa cells. The cells were 4% formaldehyde fixed for 10 minutes at room temperature and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab68218 at 5µg/ml) overnight at +4°C. The secondary antibody (pseudo-colored green) was Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-CAMKIV antibody, prediluted - ab27490 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
paraffin embedded formalin fixed human brain tissue section stained with anti CAMKIV (ab27490).

Anti-CAMK4 / CaMK IV Antibody (aa363-412) - LS-C170139 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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