CAMK4

Gene Symbol	CAMK4
Entrez Gene	814
Alt Symbol	CaMK IV, CaMK-GR, IV, caMK
Species	Human
Gene Type	protein-coding
Description	calcium/calmodulin-dependent protein kinase IV
Other Description	CAM kinase IV|CAM kinase- GR|brain Ca(2+)-calmodulin-dependent protein kinase type IV|brain Ca++-calmodulin-dependent protein kinase type IV|caM kinase-GR|calcium/calmodulin-dependent protein kinase type IV|calcium/calmodulin-dependent protein kinase type IV catalytic chain
Swissprots	Q16566 D3DSZ7
Accessions	EAW49032 EAW49033 EAW49034 Q16566 AK311662 AK312840 BAG35694 AL833368 BC016695 AAH16695 BC025687 AAH25687 BG721313 D30742 BAA06403 DA396146 DQ892902 ABM83828 DQ893195 ABM84121 DQ893196 ABM84122 DQ896523 ABM87522 DQ896524 ABM87523 DQ896525 ABM87524 DQ896526 ABM87525 L17000 AAA35639 L24959 AAA18251 XR_948301 XR_948302 XR_948303 NM_001744 NP_001735
Function	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA
Subcellular Location	Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. {ECO:0000269|PubMed:12065094, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8397199}.
Top Pathways	cAMP signaling pathway, Long-term potentiation, Oxytocin signaling pathway, Alcoholism, Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CAMK4-Over-expression-Lysate - LY10653a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CAMK4 293T Cell Transient Overexpression Lysate(Denatured) - H00000814-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CAMK4 293 Cell Lysate - 400650 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CaMKIV Overexpression Lysate (Native) - NBL1-08666 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CaMKIV (h): 293T Lysate - sc-114186 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CaMKIV (h9): 293 Lysate - sc-158335 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CAMK4 Over-expression Lysate Product - GWB-95D082 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human CAMK4 / CaMKIV Insect Cell Lysate (WB positive control) - 10664-H09BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CAMK4 Baculovirus-Insect cells Transfected Lysate (positive control) (denatured) - orb232837 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

CaMKIV Overexpression Lysate (Denatured) - H00000814-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human CAMK4 Knockdown Stable Cell Line - CSC-DC002322 from Creative biogene Category Cell Line Species Human

Search more