CTNNB1

Gene Symbol CTNNB1
Entrez Gene 1499
Alt Symbol CTNNB, MRD19, armadillo
Species Human
Gene Type protein-coding
Description catenin (cadherin-associated protein), beta 1, 88kDa
Other Description catenin beta-1
Swissprots Q8NEW9 P35222 Q9H391 A8K1L7 Q8NI94
Accessions AAD32267 AAL89457 AAR18817 ACD11099 ACD11101 AEW16366 CCH22596 EAW64625 EAW64626 EAW64627 EAW64628 P35222 AB062292 BAB93475 AB451264 BAG70078 AB451392 BAG70206 AK095242 AK289932 BAF82621 AK294778 BAG57905 AK296790 BAG59368 AK299954 BAG61781 AK314776 BC058926 AAH58926 BX648430 DA216720 EU446854 ABZ92383 U38440 X87838 CAA61107 Z19054 CAA79497 XM_005264886 XP_005264943 XM_006712983 XP_006713046 XM_006712984 XP_006713047 XM_006712985 XP_006713048 NM_001098209 NP_001091679 NM_001098210 NP_001091680 NM_001904 NP_001895
Function Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:212
Subcellular Location Cytoplasm. Nucleus {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell
Tissue Specificity Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). {ECO:0000269|PubMed:11703283, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17289029}.
Top Pathways Proteoglycans in cancer, HTLV-I infection, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

β-Catenin (D10A8) XP ® Rabbit mAb (Biotinylated) - 13727 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10A8
Western blot analysis of extracts from 3T3 and HeLa cells using β-Catenin (D10A8) XP ® Rabbit mAb (Biotinylated).

β-Catenin (L54E2) Mouse mAb (Alexa Fluor ® 555 Conjugate) - 5612 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone L54E2
Confocal immunofluorescent analysis of HeLa (left) and NCI-H28 (right) cells using β-Catenin (L54E2) Mouse mAb (Alexa Fluor ® 555 Conjugate) (red) and a Histone H3 Antibody (green).

Non-phospho (Active) β-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate) - 13537 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D13A1
Flow cytometric analysis of K-562 cells, untreated (blue) or treated with CHIR99021 (3 μM, 48 hr) (green) using Non-phospho (Active) β-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate).

β-Catenin (L54E2) Mouse mAb (PE Conjugate) - 6898 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone L54E2
Flow cytometric analysis of NCI-H28 cells (blue) and HeLa cells (green) using β-Catenin (L54E2) Mouse mAb (PE Conjugate).

β-Catenin (L54E2) Mouse mAb (Biotinylated) - 5265 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (400 assays)
Host Mouse
Clonality Monoclonal
Clone L54E2
Flow cytometric analysis of HeLa cells using β-Catenin (L54E2) Mouse mAb (Biotinylated) (blue) compared to Mouse (MOPC-21) mAb IgG1 Isotype Control (Biotinylated) #4097 (red).

β-Catenin (L54E2) Mouse mAb (Alexa Fluor ® 488 Conjugate) - 2849 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone L54E2
Confocal immunofluorescent analysis of rat heart using β-Catenin (L54E2) Mouse mAb (Alexa Fluor ® 488 Conjugate (green). and Desmin (D93F5) XP ® Rabbit mAb (red). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).

β-Catenin (L54E2) Mouse mAb (Alexa Fluor ® 647 Conjugate) - 4627 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone L54E2
Confocal immunofluorescent analysis of HeLa (left) and NCI-H28 cells (right) using β-Catenin (L54E2) Mouse mAb (Alexa Fluor ® 647 Conjugate) (blue pseudocolor) and Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb (Alexa Fluor ® 488 Conjugate) #9683 (green). Actin filaments have been labeled with DY-554 phalloidin (red).

Phospho-β-Catenin (Ser675) (D2F1) XP ® Rabbit mAb - 4176 from Cell Signaling Technology

Prices $119.00, $318.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2F1
Western blot analysis of extracts from MKN-45 and SK-N-MC cells, untreated or treated with λ phosphatase for 1 hour or forskolin (FSK) for 30 minutes, using Phospho-β-Catenin (Ser675) (D2F1) XP ® Rabbit mAb (upper) or β-Catenin (6B3) Rabbit mAb #9582 (lower).

Phospho-β-Catenin (Thr41/Ser45) Antibody - 9565 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells pretreated with 20 mM LiCl for 30 minutes and then with 50 nM calyculin A, using Phospho-β-Catenin (Thr41/Ser45) Antibody (upper) or β-Catenin Antibody #9562 (lower).

Phospho-β-Catenin (Ser675) Antibody - 9567 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SK-N-MC cells, treated with forskolin (FSK) for 30 minutes or λ phosphatase for 1 hour, using Phospho-β-Catenin (Ser675) Antibody (upper) or β-Catenin Antibody (Amino-terminal Antigen) #9581 (lower).

Phospho-β-Catenin (Ser552) (D8E11) Rabbit mAb - 5651 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8E11
Western blot analysis of extracts from SK-N-MC and NTERA-2 cells, untreated or λ phosphatase-treated, using

Phospho-β-Catenin (Ser45) Antibody - 9564 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HEK293 cells untreated and treated with calyculin A (50 nM for 30 minutes), using Phospho-β-Catenin (upper) and β-Catenin Antibody #9562 (lower).

Phospho-β-Catenin (Ser33/37) Antibody - 2009 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SW620 cells, untreated or treated with λ phosphatase, using Phospho-β-Catenin (Ser33/37) Antibody.

Phospho-β-Catenin (Ser552) Antibody - 9566 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from SK-N-MC cells, treated with forskolin (FSK) for 30 minutes, or the lysate was treated with λ phosphatase for 1 hour, using Phospho-β-Catenin (Ser552) Antibody (upper) or β-Catenin Antibody (Amino-terminal Antigen) #9581 (bottom).

Phospho-β-Catenin (Ser33/37/Thr41) Antibody - 9561 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, pretreated with 20 mM LiCl for 30 minutes and then with 50 nM calyculin A, using Phospho-β-Catenin (Ser33/37/Thr41) Antibody (upper) or β-Catenin Antibody #9562 (lower).

Acetyl-β-Catenin (Lys49) Antibody - 9534 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from 293 cells, untransfected or transiently transfected with a construct expressing CBP, using Acetyl-β-Catenin (Lys49) Antibody (Top), or total β-Catenin Antibody (Amino-terminal Antigen) #9581 (Bottom).

Acetyl-β-Catenin (Lys49) (D7C2) Rabbit mAb - 9030 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7C2
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing CBP (+), using Acetyl-β-Catenin (Lys49) (D7C2) Rabbit mAb (upper), β-Catenin (D10A8) XP ® Rabbit mAb #8480 (middle), and β-Actin (D6A8) Rabbit mAb #8457 (lower).

β-Catenin (D10A8) XP ® Rabbit mAb - 8480 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10A8
Western blot analysis of extracts from various cell lines using β-Catenin (D10A8) XP ® Rabbit mAb.

Non-phospho (Active) β-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb - 8814 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D13A1
Western blot analysis of extracts from 293T cells, untreated (-) or treated (+) with LiCl (20 mM, 20 hr at 37ºC), using Non-phospho (Active) β-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (left) and β-Catenin Antibody #9562 (right). Equal protein loading was confirmed using β-Tubulin (9F3) Rabbit mAb #2128.

β-Catenin Antibody (Carboxy-terminal Antigen) - 9587 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell extracts from 293 and NIH/3T3 cells using β-Catenin Antibody (Carboxy-terminal Antigen).

β-Catenin (6B3) Rabbit mAb - 9582 from Cell Signaling Technology

Prices $99.00, $256.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 6B3
Western blot analysis of total cell lysates from 293, Rat2 and COS cells, using β-Catenin (6B3) Rabbit mAb.

β-Catenin (L54E2) Mouse mAb (IF Preferred) - 2677 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (200 assays)
Host Mouse
Clonality Monoclonal
Clone L54E2
Confocal immunofluorescent analysis of HeLa (left) and NCI-H28 cells (right) using β-Catenin (L54E2) Mouse mAb

β-Catenin (L87A12) Mouse mAb - 2698 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L87A12
Western blot analysis of extracts from various cell lines using β-Catenin (L87A12) Mouse mAb.

β-Catenin Antibody (Amino-terminal Antigen) - 9581 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell extracts from 293 and NIH/3T3 cells, using β-Catenin Antibody (Amino-terminal Antigen).

β-Catenin Antibody - 9562 from Cell Signaling Technology

Prices $246.00, $596.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293, HeLa, NIH/3T3 and C6 cells using β-Catenin Antibody.
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