CTNNB1

Gene Symbol	CTNNB1
Entrez Gene	1499
Alt Symbol	CTNNB, MRD19, armadillo
Species	Human
Gene Type	protein-coding
Description	catenin (cadherin-associated protein), beta 1, 88kDa
Other Description	catenin beta-1
Swissprots	Q8NEW9 P35222 Q9H391 A8K1L7 Q8NI94
Accessions	AAD32267 AAL89457 AAR18817 ACD11099 ACD11101 AEW16366 CCH22596 EAW64625 EAW64626 EAW64627 EAW64628 P35222 AB062292 BAB93475 AB451264 BAG70078 AB451392 BAG70206 AK095242 AK289932 BAF82621 AK294778 BAG57905 AK296790 BAG59368 AK299954 BAG61781 AK314776 BC058926 AAH58926 BX648430 DA216720 EU446854 ABZ92383 U38440 X87838 CAA61107 Z19054 CAA79497 XM_005264886 XP_005264943 XM_006712983 XP_006713046 XM_006712984 XP_006713047 XM_006712985 XP_006713048 NM_001098209 NP_001091679 NM_001098210 NP_001091680 NM_001904 NP_001895
Function	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:212
Subcellular Location	Cytoplasm. Nucleus {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell
Tissue Specificity	Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). {ECO:0000269|PubMed:11703283, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17289029}.
Top Pathways	Proteoglycans in cancer, HTLV-I infection, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total β-Catenin Sandwich ELISA Kit - 7308 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total β-Catenin Sandwich ELISA Antibody Pair - 7309 from Cell Signaling Technology Category Antibody Pair

beta Catenin pSer45 + Total PhosphoTracer ELISA Kit - ab119656 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests

beta-Catenin (pS45) PhosphoTracer ELISA Kit - ab119619 from Abcam Category ELISA Kit Sensitivity 10000 cells/well Range 10000 cells/well - 100000 cells/well

beta-Catenin Total PhosphoTracer ELISA Kit - ab119620 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 2000 cells/well Range 2000 cells/well - 100000 cells/well

Human CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F4396 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 6.7 pg/ml Range 31.2-2000 pg/ml

Mouse CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F4891 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 5.9 pg/ml Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Tyr654) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1329 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 31.2-2000 pg/ml

Mouse/Human/Rat CTNNB1 / Beta Catenin ELISA Kit (Cell-Based ELISA) - LS-F1859 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Ser37) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1460 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Thr41, Ser45) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1461 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Tyr489) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1652 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 31.2-2000 pg/ml

Rat CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F7875 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 31.2 pg/ml Range 31.2-2000 pg/ml

Human CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F11242 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 31.2-2000 pg/ml

Rat CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F11243 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 31.2-2000 pg/ml

Rabbit anti-Beta-catenin Antibody, Affinity Purified - PLA0230 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human Total beta-Catenin DuoSet IC Economy Pack, 15 Plt - DYC1329E from R&D Systems Category ELISA Kit

Human Total beta-Catenin DuoSet IC ELISA - DYC1329-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates) Range 312.00 - 20,000 pg/mL

Human Total beta-Catenin DuoSet IC, 5 Plate - DYC1329-5 from R&D Systems Category ELISA Kit

Human Total beta-Catenin Surveyor IC - SUV1329 from R&D Systems Category ELISA Kit Prices $529.00 Sizes 1 kit

Human/Mouse Total beta-Catenin Cell-Based ELISA - KCB1329 from R&D Systems Category ELISA Kit Prices $459.00 Sizes 1 kit

beta Catenin ELISA kit - 55R-IB09614 from Fitzgerald Category ELISA Kit Prices $805.00 Sizes 96 wells

Catenin Beta 1 (CTNNb1), Human, ELISA Kit - SEB021Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 6.4pg/mL Range 15.6-1,000pg/mL

Catenin beta-1, CTNNB1, Human, ELISA Kit - E1021h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.312-20 ng/mL

Catenin beta-1, Human, ELISA Kit - CSB-E08963h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Search more