| Gene Symbol |
ANAPC1
|
| Entrez Gene |
64682
|
| Alt Symbol |
APC1, MCPR, TSG24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anaphase promoting complex subunit 1
|
| Other Description |
anaphase-promoting complex 1 (meiotic checkpoint regulator)|anaphase-promoting complex subunit 1|cyclosome subunit 1|mitotic checkpoint regulator|testis-specific gene 24 protein
|
| Swissprots |
Q9BSE6 Q9H8D0 Q2M3H8 Q9H1A4
|
| Accessions |
EAW52095 Q9H1A4 AI421643 AJ278357 CAC19484 AK023807 BAB14687 AK094527 AL832013 BC005089 AAH05089 BC104902 AAI04903 BC104904 AAI04905 BX282336 DQ786207 DQ786300 XM_011511633 XP_011509935 XM_011511634 XP_011509936 XM_011511635 XP_011509937 XM_011511636 XP_011509938 XM_011511637 XP_011509939 NM_022662 NP_073153
|
| Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.
|
| Top Pathways |
Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection
|