ANAPC1

Gene Symbol ANAPC1
Entrez Gene 64682
Alt Symbol APC1, MCPR, TSG24
Species Human
Gene Type protein-coding
Description anaphase promoting complex subunit 1
Other Description anaphase-promoting complex 1 (meiotic checkpoint regulator)|anaphase-promoting complex subunit 1|cyclosome subunit 1|mitotic checkpoint regulator|testis-specific gene 24 protein
Swissprots Q9BSE6 Q9H8D0 Q2M3H8 Q9H1A4
Accessions EAW52095 Q9H1A4 AI421643 AJ278357 CAC19484 AK023807 BAB14687 AK094527 AL832013 BC005089 AAH05089 BC104902 AAI04903 BC104904 AAI04905 BX282336 DQ786207 DQ786300 XM_011511633 XP_011509935 XM_011511634 XP_011509936 XM_011511635 XP_011509937 XM_011511636 XP_011509938 XM_011511637 XP_011509939 NM_022662 NP_073153
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.
Top Pathways Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

APC1 (D1E9D) Rabbit mAb - 13329 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1E9D
Western blot analysis of extracts from 293T cells, transfected with 100nM SignalSilence® Control siRNA (Unconjugated) #6568 (-), SignalSilence® APC1 siRNA I #13441 (+), or SignalSilence® APC1 siRNA II #13506 (+), using APC1 (D1E9D) Rabbit mAb (upper) or GAPDH (D16H11) XP® Rabbit mAb #5174 (lower). The APC1 (D1E9D) Rabbit mAb confirms silencing of APC1, while the GAPDH (D16H11) XP® Rabbit mAb is used as a loading control.

APC1 (H-300) - sc-20983 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

APC1 (P-20) - sc-23963 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Apc1 (phospho S688) antibody - ab61072 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ab61072 at 1/50-1/100 dilution with or without immunising phosphopeptide.

Anti-Apc1 antibody - ab133397 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labelling Apc1 with ab133397 at 5 µg/ml, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Apc1 antibody - ab61187 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue using ab61187 at 1/50 dilution. Samples were treated -/+ peptide.

Anti-Apc1 antibody - ab14207 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANAPC1 / APC1 Antibody (Ser355) - LS-C18982 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANAPC1 / APC1 Antibody (phospho-Ser377) - LS-C69090 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANAPC1 / APC1 Antibody (aa500-550) - LS-C288441 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ANAPC1 / APC1 Antibody (aa321-370) - LS-C118340 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using APC1 (Ab-355) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ANAPC1 / APC1 Antibody (phospho-Ser355) - LS-C18983 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-APC1 pS355 Antibody - Western Blot. Western blot of Affinity Purified anti-APC1 pS355 antibody shows detection of a band ~215 kD corresponding to phosphorylated human APC1 (arrowhead). Lane 1 shows lysate from asynchronous cells. Lane 2 shows lysate from cells treated with thymidine to synchronize cells at the G1/S boundary. Lane 3 shows lysate from cells treated with nocodazole to synchronize cells at the M phase. Phosphorylated APC1 is mostly present only in cell preparations arrested at cell division. Each lane contains approximately 30 ug of HeLa S3 whole cell lysates separated by 12.5% SDS-PAGE followed by transfer to nitrocellulose. After blocking with 5% non-fat dry milk in TTBS, the membrane was probed with the primary antibody diluted to 1:500 for 1 h at room temperature followed by washes and reaction with a 1:5000 dilution of HRP Gt-a-Rabbit IgG [H&L] MX (LS-C60865) for 45 min at room temperature. ECL reagent was used for detection. Other detection systems will yield si

Anti-ANAPC1 / APC1 Antibody (aa1311-1360) - LS-C119530 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using Cyclosome 1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ANAPC1 / APC1 Antibody (phospho-Ser355) - LS-C198633 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using APC1 (Phospho-Ser355) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-ANAPC1 / APC1 Antibody (aa654-703) - LS-C117939 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using APC1 (Ab-688) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ANAPC1 / APC1 Antibody (phospho-Ser688) - LS-C198634 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma, using APC1 (Phospho-Ser688) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-ANAPC1 / APC1 Antibody - LS-C332600 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using ANAPC1 antibody.

Anti-ANAPC1 / APC1 Antibody (Glu684) - LS-C176485 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of APC1 (E684) pAb in paraffin-embedded human breast carcinoma tissue.

Anti-ANAPC1 / APC1 Antibody (phospho-Ser377) IHC-plus™ - LS-B68 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ANAPC1 antibody IHC of human pancreatic carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B68 concentration 10 ug/ml.

Anti-ANAPC1 / APC1 Antibody (C-Terminus) IHC-plus™ - LS-B6979 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ANAPC1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6979 concentration 5 ug/ml.

Apc1 Antibody - NBP1-77375 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Apc1 Antibody [NBP1-77375] - analysis of APC1 in SK-N-SH cell lysate with APC1 antibody at (A) 1 and (B) 2 ug/ml.

Apc1 Antibody - NBP2-37901 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Apc1 Antibody [NBP2-37901] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG. Lane 4: Human Plasma. Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

Apc1 [p Ser377] Antibody - NB600-895 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Apc1 [p Ser377] Antibody [NB600-895] - Analysis of a band 215 kDa corresponding to phosphorylated human APC1 (arrowhead). Lane 1 shows lysate from asynchronous cells. Lane 2 shows lysate from cells treated with nocodazole. While some phosphorylated APC1 is present in untreated cell, the amount of phosphorylated protein is increased in cell preparations arrested in mitosis. Each lane contains approximately 30 ug of HeLa whole cell lysates, separated by 4-8% SDS-PAGE followed by transfer to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:1,000 overnight at 4C followed by washes and reaction with a 1:10,000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L] MX for 45 min at room temperature.

Apc1 Antibody - NB100-86985 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Apc1 Antibody [NB100-86985] - Detection of Human and Mouse APC1 by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg), and mouse NIH3T3 (M; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-APC1 antibody NB100-86985 used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. APC1 was also immunoprecipitated by another rabbit anti-APC1 antibody which recognizes an upstream epitope.

Apc1 Antibody - NBP2-37880 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Apc1 Antibody [NBP2-37880] - Staining of human pancreas shows distinct cytoplasmic positivity in exocrine glandular cells.
Search more