| Gene Symbol |
ATAD2
|
| Entrez Gene |
29028
|
| Alt Symbol |
ANCCA, CT137, PRO2000
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase family, AAA domain containing 2
|
| Other Description |
AAA nuclear coregulator cancer-associated protein|ATPase family AAA domain-containing protein 2
|
| Swissprots |
Q8N890 Q68CQ0 Q6PJV6 Q658P2 Q6PL18 Q9UHS5 Q14CR1
|
| Accessions |
EAW92033 EAW92034 EAW92035 EAW92036 Q6PL18 AF118088 AAF22032 AK097133 BAC04959 AL833653 CAH56229 AY598335 AAT06746 BC007123 BC010686 AAH10686 BC019909 AAH19909 BC112942 BC113656 AAI13657 BC143716 BP314109 CA441499 CB159561 CR749832 CAH18688 JF432508 ADZ15725 XM_011516994 XP_011515296 XM_011516995 XP_011515297 XM_011516996 XP_011515298 XR_928326 NM_014109 NP_054828
|
| Function |
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17998543}.
|
| Tissue Specificity |
Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. {ECO:0000269|PubMed:15721472, ECO:0000269|PubMed:17076897, ECO:0000269|PubMed:17660802}.
|