Gene Symbol | ATAD2 |
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Entrez Gene | 29028 |
Alt Symbol | ANCCA, CT137, PRO2000 |
Species | Human |
Gene Type | protein-coding |
Description | ATPase family, AAA domain containing 2 |
Other Description | AAA nuclear coregulator cancer-associated protein|ATPase family AAA domain-containing protein 2 |
Swissprots | Q8N890 Q68CQ0 Q6PJV6 Q658P2 Q6PL18 Q9UHS5 Q14CR1 |
Accessions | EAW92033 EAW92034 EAW92035 EAW92036 Q6PL18 AF118088 AAF22032 AK097133 BAC04959 AL833653 CAH56229 AY598335 AAT06746 BC007123 BC010686 AAH10686 BC019909 AAH19909 BC112942 BC113656 AAI13657 BC143716 BP314109 CA441499 CB159561 CR749832 CAH18688 JF432508 ADZ15725 XM_011516994 XP_011515296 XM_011516995 XP_011515297 XM_011516996 XP_011515298 XR_928326 NM_014109 NP_054828 |
Function | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17998543}. |
Tissue Specificity | Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. {ECO:0000269|PubMed:15721472, ECO:0000269|PubMed:17076897, ECO:0000269|PubMed:17660802}. |
ATAD2 CRISPR/Cas9 KO Plasmid (h) - sc-412018 from Santa Cruz Biotechnology
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ATAD2 HDR Plasmid (h) - sc-412018-HDR from Santa Cruz Biotechnology
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ATAD2 Double Nickase Plasmid (h) - sc-412018-NIC from Santa Cruz Biotechnology
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ATAD2 Double Nickase Plasmid (h2) - sc-412018-NIC-2 from Santa Cruz Biotechnology
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ATAD2 CRISPR Activation Plasmid (h) - sc-412018-ACT from Santa Cruz Biotechnology
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ATAD2 CRISPR Activation Plasmid (h2) - sc-412018-ACT-2 from Santa Cruz Biotechnology
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ATAD2 Lentiviral Activation Particles (h) - sc-412018-LAC from Santa Cruz Biotechnology
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ATAD2 Lentiviral Activation Particles (h2) - sc-412018-LAC-2 from Santa Cruz Biotechnology
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ATAD2 siRNA (h) - sc-77615 from Santa Cruz Biotechnology
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ATAD2 shRNA Plasmid (h) - sc-77615-SH from Santa Cruz Biotechnology
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ATAD2 shRNA (h) Lentiviral Particles - sc-77615-V from Santa Cruz Biotechnology
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ATAD2 RNAi - H00029028-R01 from Novus Biologicals
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MISSION® esiRNA - EHU121691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3624 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3624 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06103 from Sigma-Aldrich
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ATAD2 siRNA (Human) - CRH9160 from Cohesion Biosciences
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ATAD2 - MBS8238079 from MyBioSource
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shRNA set against Human ATAD2 (NM_014109.3) - SHH241806 from Creative biogene
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shRNA set against Human ATAD2(NM_014109.3) - SHG078832 from Creative biogene
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Human ATAD2 siRNA - orb269662 from Biorbyt
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ATAD2 shRNA Plasmid (Human) - CHH9160 from Cohesion Biosciences
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ATAD2 miRNA 3'UTR clone - MiUTR1H-00651 from Creative biogene
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