| Gene Symbol |
NCAPD2
|
| Entrez Gene |
9918
|
| Alt Symbol |
CAP-D2, CNAP1, hCAP-D2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
non-SMC condensin I complex, subunit D2
|
| Other Description |
XCAP-D2 homolog|chromosome condensation related SMC associated protein 1|chromosome condensation-related SMC-associated protein 1|chromosome-associated protein D2|condensin complex subunit 1
|
| Swissprots |
Q8N6U3 Q15021 D3DUR4
|
| Accessions |
EAW88788 EAW88789 EAW88790 Q15021 AK022511 BAG51082 AK125155 BAC86066 AK128354 BAG54665 AK303310 BAG64379 AL548223 BC016913 AAH16913 BC028182 AAH28182 CN307514 D63880 BAA09930 DQ573571 NM_014865 NP_055680
|
| Function |
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. {ECO:0000269|PubMed:11136719}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
|