NCAPD2
| Gene Symbol | NCAPD2 |
|---|---|
| Entrez Gene | 9918 |
| Alt Symbol | CAP-D2, CNAP1, hCAP-D2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | non-SMC condensin I complex, subunit D2 |
| Other Description | XCAP-D2 homolog|chromosome condensation related SMC associated protein 1|chromosome condensation-related SMC-associated protein 1|chromosome-associated protein D2|condensin complex subunit 1 |
| Swissprots | Q8N6U3 Q15021 D3DUR4 |
| Accessions | EAW88788 EAW88789 EAW88790 Q15021 AK022511 BAG51082 AK125155 BAC86066 AK128354 BAG54665 AK303310 BAG64379 AL548223 BC016913 AAH16913 BC028182 AAH28182 CN307514 D63880 BAA09930 DQ573571 NM_014865 NP_055680 |
| Function | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. {ECO:0000269|PubMed:11136719}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. |
hCAP-D2 CRISPR/Cas9 KO Plasmid (h) - sc-408804 from Santa Cruz Biotechnology
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hCAP-D2 HDR Plasmid (h) - sc-408804-HDR from Santa Cruz Biotechnology
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hCAP-D2 Double Nickase Plasmid (h) - sc-408804-NIC from Santa Cruz Biotechnology
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hCAP-D2 Double Nickase Plasmid (h2) - sc-408804-NIC-2 from Santa Cruz Biotechnology
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hCAP-D2 CRISPR Activation Plasmid (h) - sc-408804-ACT from Santa Cruz Biotechnology
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hCAP-D2 CRISPR Activation Plasmid (h2) - sc-408804-ACT-2 from Santa Cruz Biotechnology
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hCAP-D2 Lentiviral Activation Particles (h) - sc-408804-LAC from Santa Cruz Biotechnology
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hCAP-D2 Lentiviral Activation Particles (h2) - sc-408804-LAC-2 from Santa Cruz Biotechnology
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hCAP-D2 siRNA (h) - sc-60774 from Santa Cruz Biotechnology
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hCAP-D2 shRNA Plasmid (h) - sc-60774-SH from Santa Cruz Biotechnology
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hCAP-D2 shRNA (h) Lentiviral Particles - sc-60774-V from Santa Cruz Biotechnology
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CNAP1 RNAi - H00009918-R01 from Novus Biologicals
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MISSION® esiRNA - EHU005851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15002 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15002 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01175 from Sigma-Aldrich
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NCAPD2 siRNA (Human) - CRH6663 from Cohesion Biosciences
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shRNA set against Human NCAPD2 (NM_014865.3) - SHH349804 from Creative biogene
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Human NCAPD2 siRNA - orb267165 from Biorbyt
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NCAPD2 shRNA Plasmid (Human) - CHH6663 from Cohesion Biosciences
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NCAPD2 miRNA 3'UTR clone - MiUTR3H-15575 from Creative biogene
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