MPZL1

Gene Symbol MPZL1
Entrez Gene 9019
Alt Symbol MPZL1b, PZR, PZR1b, PZRa, PZRb
Species Human
Gene Type protein-coding
Description myelin protein zero-like 1
Other Description immunoglobulin family transmembrane protein|myelin protein zero-like protein 1|protein zero related|protein zero-related
Swissprots Q9NYK4 Q9UL20 B2REB9 O95297 B2REC0 Q8IX11 Q5R332 Q9BWZ3
Accessions AAO14646 AAO14647 EAW90800 EAW90801 EAW90802 EAW90803 O95297 AF087020 AAC72231 AF092424 AAD55346 AF092425 AAD55347 AF095726 AAF00083 AF095727 AAF00084 AF181660 AAF00621 AF239756 AAF63499 AF478447 AAO14645 AI635633 AK024700 BAB14967 AK075334 AK291249 BAF83938 AK297112 BAH12501 AK307250 AK315546 BAG37924 AL035302 CAA22907 AL035308 CAA22913 AW292498 AY359019 AAQ89378 BC000984 BC007881 AAH07881 BC019890 AAH19890 BE616859 BF528837 BT019542 AAV38349 BU155202 CA397666 CD556632 CD557072 CR542160 CAG46957 DA725074 HQ447352 ADQ31838 NM_001146191 NP_001139663 NM_003953 NP_003944 NM_024569 NP_078845
Function Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. {ECO:0000269|PubMed:12410637, ECO:0000269|PubMed:12684038, ECO:0000269|PubMed:9792637}.
Top Pathways Cell adhesion molecules (CAMs)

Phospho-PZR (Tyr241) (D6F9) Rabbit mAb - 8131 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6F9
Western blot analysis of extracts from BAE cells, untreated or H 2 O 2 -treated (0.3 mM, 30 min) and untreated HeLa cells using Phospho-PZR (Tyr241) (D6F9) Rabbit mAb.

Phospho-PZR (Tyr263) Antibody - 5543 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from BAEC cells, untreated or H 2 O 2 -treated (0.3 mM for 30 min), using Phospho-PZR (Tyr263) Antibody (upper) and total PZR Antibody # 4157 (lower).

Phospho-PZR (Tyr263) (D6A5) Rabbit mAb - 8088 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6A5
Western blot analysis of extracts from BAE cells, untreated or H 2 O 2 -treated (0.3 mM, 30 min) and untreated HeLa cells, using Phospho-PZR (Tyr263) (D6A5) Rabbit mAb.

PZR (D17B10) XP ® Rabbit mAb - 9893 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D17B10
Western blot analysis of extracts from various cell lines using PZR (D17B10) XP ® Rabbit mAb.

PZR Antibody - 4157 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and HEK293T cells using PZR Antibody.

MPZL1 (P-13) - sc-160539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MPZL1 (H-99) - sc-366775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MPZL1 (H-99): sc-366775. Western blot analysis of MPZL1 expression in HL-60 (A) and Hep G2 (B) whole cell lysates.

Anti-MPZL antibody - ab67152 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MPZL antibody (ab67152) at 1/500 dilutionLane 1 : transfected 293T cell lysate Lane 2 : non transfected 293T cell lysate Lysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-MPZL antibody [EPR9229] - ab151541 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9229
All lanes : Anti-MPZL antibody [EPR9229] (ab151541) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MPZL1 Antibody (Tyr263) - LS-C191241 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MPZL1 Antibody (aa107-156) - LS-C110879 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MPZL1 antibody LS-C110879 Western blot of PANC1 cell lysate.

Anti-MPZL1 Antibody (aa225-275) - LS-C291045 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PZR by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) prepared using NETN buffer from 293T cells. Antibodies: Affinity purified rabbit anti-PZR antibody used for IP at 6 ug per reaction. PZR was also immunoprecipitated by rabbit anti-PZR antibody BL16518. For blotting immunoprecipitated PZR, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

MPZL1 Antibody - NBP1-83625 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MPZL1 Antibody [NBP1-83625] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

MPZL1 Antibody - H00009019-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: MPZL1 Antibody [H00009019-B01P] - Analysis of MPZL1 expression in transfected 293T cell line by MPZL1 polyclonal antibody. Lane 1: MPZL1 transfected lysate(29.59 KDa). Lane 2: Non-transfected lysate.

MPZL1 Antibody - H00009019-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-MPZL1 antibody produced in rabbit - SAB1411600 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MPZL1: <B>Cat. No. SAB1411600</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~29.1 kDa using MPZL1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-MPZL1 antibody produced in rabbit - HPA026966 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MPZL1: <B>Cat. No. HPA026966</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells of tubules.

Anti-MPZL1 (246-260) antibody produced in rabbit - SAB1100766 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-MPZL1 (246-260) : <B>Cat. No. SAB1100766</B>: Immunofluorescence of HUVEC cells using MPZL1 (246-260) , Cat. No. SAB1100766 (red) at a 1:100 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-MPZL1 (96-110) antibody produced in rabbit - SAB1100765 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-MPZL1 (96-110) : <B>Cat. No. SAB1100765</B>: Immunofluorescence of HUVEC cells using MPZL1 (96-110) , Cat. No. SAB1100765 (red) at a 1:200 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-MPZL1 antibody produced in mouse - SAB1406763 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MPZL1: <B>Cat. No. SAB1406763</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~29.6 kDa using MPZL1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

MPZL1 antibody - middle region (ARP46390_P050) - ARP46390_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MPZL1 antibody, Internal - GTX46451 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

MPZL1 antibody - 70R-18585 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

MPZL1 antibody - 70R-6628 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

MPZL1 antibody - 13158-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Human heart were subjected to SDS PAGE followed by western blot with 13158-1-AP(MPZL1 Antibody) at dilution of 1:800
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