MPZL1

Gene Symbol MPZL1
Entrez Gene 9019
Alt Symbol MPZL1b, PZR, PZR1b, PZRa, PZRb
Species Human
Gene Type protein-coding
Description myelin protein zero-like 1
Other Description immunoglobulin family transmembrane protein|myelin protein zero-like protein 1|protein zero related|protein zero-related
Swissprots Q9NYK4 Q9UL20 B2REB9 O95297 B2REC0 Q8IX11 Q5R332 Q9BWZ3
Accessions AAO14646 AAO14647 EAW90800 EAW90801 EAW90802 EAW90803 O95297 AF087020 AAC72231 AF092424 AAD55346 AF092425 AAD55347 AF095726 AAF00083 AF095727 AAF00084 AF181660 AAF00621 AF239756 AAF63499 AF478447 AAO14645 AI635633 AK024700 BAB14967 AK075334 AK291249 BAF83938 AK297112 BAH12501 AK307250 AK315546 BAG37924 AL035302 CAA22907 AL035308 CAA22913 AW292498 AY359019 AAQ89378 BC000984 BC007881 AAH07881 BC019890 AAH19890 BE616859 BF528837 BT019542 AAV38349 BU155202 CA397666 CD556632 CD557072 CR542160 CAG46957 DA725074 HQ447352 ADQ31838 NM_001146191 NP_001139663 NM_003953 NP_003944 NM_024569 NP_078845
Function Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. {ECO:0000269|PubMed:12410637, ECO:0000269|PubMed:12684038, ECO:0000269|PubMed:9792637}.
Top Pathways Cell adhesion molecules (CAMs)

MPZL1 CRISPR/Cas9 KO Plasmid (h) - sc-407478 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 HDR Plasmid (h) - sc-407478-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 Double Nickase Plasmid (h) - sc-407478-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 Double Nickase Plasmid (h2) - sc-407478-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 CRISPR Activation Plasmid (h) - sc-407478-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 CRISPR Activation Plasmid (h2) - sc-407478-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 Lentiviral Activation Particles (h) - sc-407478-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 Lentiviral Activation Particles (h2) - sc-407478-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MPZL1 siRNA (h) - sc-88129 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MPZL1 shRNA Plasmid (h) - sc-88129-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MPZL1 shRNA (h) Lentiviral Particles - sc-88129-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MPZL1 RNAi - H00009019-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MPZL1 RNAi - H00009019-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU076461 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14518 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14518 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MPZL1 siRNA (Human) - CRH5946 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MPZL1 (NM_003953.5) - SHH344116 from Creative biogene

Category siRNA
Species Reactivities Human

MPZL1 shRNA Plasmid (Human) - CHH5946 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MPZL1 miRNA 3'UTR clone - MiUTR4H-TG05612 from Creative biogene

Species Reactivities Human
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