| Gene Symbol |
MPZL1
|
| Entrez Gene |
9019
|
| Alt Symbol |
MPZL1b, PZR, PZR1b, PZRa, PZRb
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myelin protein zero-like 1
|
| Other Description |
immunoglobulin family transmembrane protein|myelin protein zero-like protein 1|protein zero related|protein zero-related
|
| Swissprots |
Q9NYK4 Q9UL20 B2REB9 O95297 B2REC0 Q8IX11 Q5R332 Q9BWZ3
|
| Accessions |
AAO14646 AAO14647 EAW90800 EAW90801 EAW90802 EAW90803 O95297 AF087020 AAC72231 AF092424 AAD55346 AF092425 AAD55347 AF095726 AAF00083 AF095727 AAF00084 AF181660 AAF00621 AF239756 AAF63499 AF478447 AAO14645 AI635633 AK024700 BAB14967 AK075334 AK291249 BAF83938 AK297112 BAH12501 AK307250 AK315546 BAG37924 AL035302 CAA22907 AL035308 CAA22913 AW292498 AY359019 AAQ89378 BC000984 BC007881 AAH07881 BC019890 AAH19890 BE616859 BF528837 BT019542 AAV38349 BU155202 CA397666 CD556632 CD557072 CR542160 CAG46957 DA725074 HQ447352 ADQ31838 NM_001146191 NP_001139663 NM_003953 NP_003944 NM_024569 NP_078845
|
| Function |
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. {ECO:0000269|PubMed:12410637, ECO:0000269|PubMed:12684038, ECO:0000269|PubMed:9792637}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|