MPZL1

Gene Symbol	MPZL1
Entrez Gene	9019
Alt Symbol	MPZL1b, PZR, PZR1b, PZRa, PZRb
Species	Human
Gene Type	protein-coding
Description	myelin protein zero-like 1
Other Description	immunoglobulin family transmembrane protein|myelin protein zero-like protein 1|protein zero related|protein zero-related
Swissprots	Q9NYK4 Q9UL20 B2REB9 O95297 B2REC0 Q8IX11 Q5R332 Q9BWZ3
Accessions	AAO14646 AAO14647 EAW90800 EAW90801 EAW90802 EAW90803 O95297 AF087020 AAC72231 AF092424 AAD55346 AF092425 AAD55347 AF095726 AAF00083 AF095727 AAF00084 AF181660 AAF00621 AF239756 AAF63499 AF478447 AAO14645 AI635633 AK024700 BAB14967 AK075334 AK291249 BAF83938 AK297112 BAH12501 AK307250 AK315546 BAG37924 AL035302 CAA22907 AL035308 CAA22913 AW292498 AY359019 AAQ89378 BC000984 BC007881 AAH07881 BC019890 AAH19890 BE616859 BF528837 BT019542 AAV38349 BU155202 CA397666 CD556632 CD557072 CR542160 CAG46957 DA725074 HQ447352 ADQ31838 NM_001146191 NP_001139663 NM_003953 NP_003944 NM_024569 NP_078845
Function	Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. {ECO:0000269|PubMed:12410637, ECO:0000269|PubMed:12684038, ECO:0000269|PubMed:9792637}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MPZL full length protein - ab160293 from Abcam Category Protein Source Wheat germ Species Human

Human MPZL protein fragment - ab167917 from Abcam Category Protein Source E. coli Species Human

MPZL1 Antibody Blocking Peptide - LS-E16912 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MPZL1 Recombinant Protein - H00009019-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human MPZL1 Protein - NBP2-23254 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

Human MPZL1 protein - orb191313 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

MPZL1 Blocking Peptide - 33R-4168 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MPZL1 protein (His tag) - 80R-2931 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

MPZL1 (38-162, His-tag) - AR51049PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

MPZL1 (38-162, His-tag) - AR51049PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

MPZL1 - H00009019-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

MPZL1, 38-162aa, Human, His tag, E.coli - 01-P2225 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

MPZL1 fusion protein - ag3791 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MPZL1, His-tagged - MPZL1-15869H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Myelin protein zero-like protein 1(MPZL1) - CSB-YP014775HU CSB-EP014775HU CSB-BP014775HU CSB-MP014775HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MPZL1, 38-162aa, Human, His tag, E.coli - ATGP2225 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

MPZL1 (transcript variant 1) - TP303176 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Human Myelin Protein Zero-Like 1 protein (C-His) - orb311900 from Biorbyt Category Protein Prices $179.00, $281.00, $893.00, $1,411.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

MPZL1 Recombinant Protein Antigen - NBP1-83625PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MPZL1 Peptide, Human - M34GP09694H from Creative Peptides Category Peptide Source Synthetic. Species Human

MPZL1 Antibody - SH-A13687 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

MPZL1 - PAT-82224-1 from Nordic BioSite Category Protein Species Human

MPZL1 - PAT-82224-2 from Nordic BioSite Category Protein Species Human

MPZL1 Recombinant Protein Antigen - NBP2-57487PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MPZL1, Recombinant Protein - MBS204888 from MyBioSource Category Protein Prices $375.00, $925.00 Sizes 50 µg, 250 µg Source E Coli Species Human

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