Gene Symbol | DRAXIN |
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Entrez Gene | 374946 |
Alt Symbol | AGPA3119, C1orf187, UNQ3119, neucrin |
Species | Human |
Gene Type | protein-coding |
Description | dorsal inhibitory axon guidance protein |
Other Description | dorsal repulsive axon guidance protein|draxin|neural tissue-specific cysteine-rich protein |
Swissprots | B6EV15 Q6UWK8 Q5SNX0 Q8NBI3 |
Accessions | EAW71700 EAW71701 Q8NBI3 AB301919 BAG80561 AK075558 BAC11697 AK092318 BAG52531 AK311439 AY358750 AAQ89110 BC021286 BC111064 AAI11065 BM928129 XM_011541405 XP_011539707 XM_011541406 XP_011539708 NM_198545 NP_940947 |
Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255|HAMAP- Rule:MF_03060}. |
Subcellular Location | Secreted {ECO:0000305}. |
chromosome 1 open reading frame 187, ELISA Kit - MBS9332125 from MyBioSource
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Human Draxin/Neucrin ELISA - ELH-Draxin-1 from RayBiotech
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Custom Human Neucrin ELISA Kit - orb384554 from Biorbyt
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Human C1orf187 ELISA Kit - E008471 from Biobool
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Human DRAXIN ELISA Kit - E081662 from Biobool
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