Gene Symbol | DRAXIN |
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Entrez Gene | 374946 |
Alt Symbol | AGPA3119, C1orf187, UNQ3119, neucrin |
Species | Human |
Gene Type | protein-coding |
Description | dorsal inhibitory axon guidance protein |
Other Description | dorsal repulsive axon guidance protein|draxin|neural tissue-specific cysteine-rich protein |
Swissprots | B6EV15 Q6UWK8 Q5SNX0 Q8NBI3 |
Accessions | EAW71700 EAW71701 Q8NBI3 AB301919 BAG80561 AK075558 BAC11697 AK092318 BAG52531 AK311439 AY358750 AAQ89110 BC021286 BC111064 AAI11065 BM928129 XM_011541405 XP_011539707 XM_011541406 XP_011539708 NM_198545 NP_940947 |
Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255|HAMAP- Rule:MF_03060}. |
Subcellular Location | Secreted {ECO:0000305}. |
MISSION® esiRNA - EHU080841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4622 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4622 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04227 from Sigma-Aldrich
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DRAXIN siRNA (Human) - CRJ7646 from Cohesion Biosciences
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Draxin CRISPR/Cas9 KO Plasmid (h) - sc-415700 from Santa Cruz Biotechnology
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Draxin HDR Plasmid (h) - sc-415700-HDR from Santa Cruz Biotechnology
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C1orf187 Double Nickase Plasmid (h) - sc-415700-NIC from Santa Cruz Biotechnology
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Draxin Double Nickase Plasmid (h2) - sc-415700-NIC-2 from Santa Cruz Biotechnology
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C1orf187 CRISPR Activation Plasmid (h) - sc-415700-ACT from Santa Cruz Biotechnology
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Draxin CRISPR Activation Plasmid (h2) - sc-415700-ACT-2 from Santa Cruz Biotechnology
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C1orf187 Lentiviral Activation Particles (h) - sc-415700-LAC from Santa Cruz Biotechnology
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Draxin Lentiviral Activation Particles (h2) - sc-415700-LAC-2 from Santa Cruz Biotechnology
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Draxin siRNA (h) - sc-88131 from Santa Cruz Biotechnology
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Draxin shRNA Plasmid (h) - sc-88131-SH from Santa Cruz Biotechnology
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Draxin shRNA (h) Lentiviral Particles - sc-88131-V from Santa Cruz Biotechnology
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DRAXIN - MBS827655 from MyBioSource
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shRNA set against Human C1orf187 (NM_198545.3) - SHH250478 from Creative biogene
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DRAXIN shRNA Plasmid (Human) - CHJ7646 from Cohesion Biosciences
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DRAXIN miRNA 3'UTR clone - MiUTR1H-01246 from Creative biogene
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