| Gene Symbol |
DRAXIN
|
| Entrez Gene |
374946
|
| Alt Symbol |
AGPA3119, C1orf187, UNQ3119, neucrin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dorsal inhibitory axon guidance protein
|
| Other Description |
dorsal repulsive axon guidance protein|draxin|neural tissue-specific cysteine-rich protein
|
| Swissprots |
B6EV15 Q6UWK8 Q5SNX0 Q8NBI3
|
| Accessions |
EAW71700 EAW71701 Q8NBI3 AB301919 BAG80561 AK075558 BAC11697 AK092318 BAG52531 AK311439 AY358750 AAQ89110 BC021286 BC111064 AAI11065 BM928129 XM_011541405 XP_011539707 XM_011541406 XP_011539708 NM_198545 NP_940947
|
| Function |
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255|HAMAP- Rule:MF_03060}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
![Western Blot: C1orf187 Overexpression Lysate (Adult Normal) [NBL1-08308] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for C1orf187.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6275_C1orf187%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08308-img0002.jpg)