Gene Symbol | E2F7 |
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Entrez Gene | 144455 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | E2F transcription factor 7 |
Other Description | E2F-7|transcription factor E2F7 |
Swissprots | Q96AV8 B5MED9 B2RMR7 B3KUP8 A6NC74 B3KTZ5 |
Accessions | EAW97338 EAW97339 EAW97340 Q96AV8 AI380315 AK023043 AK096316 BAG53257 AK097677 BAG53510 BC016658 AAH16658 BC017481 BC136366 AAI36367 BC136367 AAI36368 DB159890 XM_011537966 XP_011536268 XM_011537967 XP_011536269 XM_011537968 XP_011536270 XM_011537969 XP_011536271 NM_203394 NP_976328 |
Function | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dep |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15133492}. |
E2F-7 (H-300) - sc-66870 from Santa Cruz Biotechnology
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E2F-7 (N-20) - sc-32574 from Santa Cruz Biotechnology
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E2F-7 (R-17) - sc-32575 from Santa Cruz Biotechnology
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Anti-E2F7 antibody - ab56022 from Abcam
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Anti-E2F7 antibody - ab106832 from Abcam
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Anti-E2F7 antibody - ab123864 from Abcam
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Anti-E2F7 antibody - N-terminal - ab166727 from Abcam
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Anti-E2F7 Antibody (aa591-619, AP) - LS-C234828 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa591-619, APC) - LS-C234829 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa591-619, Biotin) - LS-C234830 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa591-619, FITC) - LS-C234831 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa53-66) - LS-C112753 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa1-50) - LS-C289739 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa591-619, PE) - LS-C234834 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa591-619, Azide-free, HRP) - LS-C249883 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa861-911) - LS-C289742 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa590-619) - LS-C320995 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa591-619) - LS-C167600 from LifeSpan Bioscience
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Anti-E2F7 Antibody (aa108-157) - LS-C31453 from LifeSpan Bioscience
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Anti-E2F7 Antibody - LS-C348746 from LifeSpan Bioscience
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Anti-E2F7 Antibody - LS-C348747 from LifeSpan Bioscience
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Anti-E2F7 Antibody - LS-C348749 from LifeSpan Bioscience
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E2F7 Antibody - NBP1-52649 from Novus Biologicals
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E2F7 Antibody - NBP1-52648 from Novus Biologicals
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E2F7 Antibody - NBP1-26399 from Novus Biologicals
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