E2F7
| Gene Symbol | E2F7 |
|---|---|
| Entrez Gene | 144455 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | E2F transcription factor 7 |
| Other Description | E2F-7|transcription factor E2F7 |
| Swissprots | Q96AV8 B5MED9 B2RMR7 B3KUP8 A6NC74 B3KTZ5 |
| Accessions | EAW97338 EAW97339 EAW97340 Q96AV8 AI380315 AK023043 AK096316 BAG53257 AK097677 BAG53510 BC016658 AAH16658 BC017481 BC136366 AAI36367 BC136367 AAI36368 DB159890 XM_011537966 XP_011536268 XM_011537967 XP_011536269 XM_011537968 XP_011536270 XM_011537969 XP_011536271 NM_203394 NP_976328 |
| Function | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dep |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15133492}. |
E2F-7 CRISPR/Cas9 KO Plasmid (h) - sc-401855 from Santa Cruz Biotechnology
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E2F-7 HDR Plasmid (h) - sc-401855-HDR from Santa Cruz Biotechnology
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E2F-7 Double Nickase Plasmid (h) - sc-401855-NIC from Santa Cruz Biotechnology
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E2F-7 Double Nickase Plasmid (h2) - sc-401855-NIC-2 from Santa Cruz Biotechnology
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E2F-7 CRISPR Activation Plasmid (h) - sc-401855-ACT from Santa Cruz Biotechnology
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E2F-7 CRISPR Activation Plasmid (h2) - sc-401855-ACT-2 from Santa Cruz Biotechnology
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E2F-7 Lentiviral Activation Particles (h) - sc-401855-LAC from Santa Cruz Biotechnology
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E2F-7 Lentiviral Activation Particles (h2) - sc-401855-LAC-2 from Santa Cruz Biotechnology
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E2F-7 siRNA (h) - sc-44590 from Santa Cruz Biotechnology
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E2F-7 shRNA Plasmid (h) - sc-44590-SH from Santa Cruz Biotechnology
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E2F-7 shRNA (h) Lentiviral Particles - sc-44590-V from Santa Cruz Biotechnology
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E2F7 RNAi - H00144455-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7609 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7609 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11879 from Sigma-Aldrich
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E2F7 siRNA (Human) - CRJ5413 from Cohesion Biosciences
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E2F7 - MBS8216230 from MyBioSource
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shRNA set against Human E2F7 (NM_203394.2) - SHH282553 from Creative biogene
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shRNA set against Human E2F7(NM_203394.2) - SHH022025 from Creative biogene
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Human E2F7 siRNA - orb275914 from Biorbyt
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E2F7 shRNA Plasmid (Human) - CHJ5413 from Cohesion Biosciences
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E2F7 miRNA 3'UTR clone - MiUTR1H-03079 from Creative biogene
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