| Gene Symbol |
E2F7
|
| Entrez Gene |
144455
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 7
|
| Other Description |
E2F-7|transcription factor E2F7
|
| Swissprots |
Q96AV8 B5MED9 B2RMR7 B3KUP8 A6NC74 B3KTZ5
|
| Accessions |
EAW97338 EAW97339 EAW97340 Q96AV8 AI380315 AK023043 AK096316 BAG53257 AK097677 BAG53510 BC016658 AAH16658 BC017481 BC136366 AAI36367 BC136367 AAI36368 DB159890 XM_011537966 XP_011536268 XM_011537967 XP_011536269 XM_011537968 XP_011536270 XM_011537969 XP_011536271 NM_203394 NP_976328
|
| Function |
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dep
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15133492}.
|