| Gene Symbol |
MYRIP
|
| Entrez Gene |
25924
|
| Alt Symbol |
SLAC2-C, SLAC2C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin VIIA and Rab interacting protein
|
| Other Description |
Slp homologue lacking C2 domains|exophilin-8|myosin-VIIa- and Rab-interacting protein|rab effector MyRIP|slp homolog lacking C2 domains c|synaptotagmin-like protein homologue lacking C2 domains-c|synaptotagmin-like protein lacking C2 domains C
|
| Swissprots |
Q9Y3V4 G3XAI8 Q32M42 Q32M41 B3KWM3 Q8IUF5 Q8NFW9 B7Z2H1 Q569F7 B3KWW4 B7Z9V3
|
| Accessions |
EAW64595 EAW64596 Q8NFW9 AB083783 BAC15555 AF396687 AAM43954 AK125334 BAG54185 AK126013 BAG54276 AK294714 BAH11857 AK310972 AK312412 AK316068 BAH14439 AL050090 CAB43262 BC092512 AAH92512 BC109311 AAI09312 BC109312 AAI09313 CF138044 DN999201 XM_011533575 XP_011531877 NM_001284423 NP_001271352 NM_001284424 NP_001271353 NM_001284425 NP_001271354 NM_001284426 NP_001271355 NM_015460 NP_056275 NR_104316
|
| Function |
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.
|