MYRIP
| Gene Symbol | MYRIP |
|---|---|
| Entrez Gene | 25924 |
| Alt Symbol | SLAC2-C, SLAC2C |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin VIIA and Rab interacting protein |
| Other Description | Slp homologue lacking C2 domains|exophilin-8|myosin-VIIa- and Rab-interacting protein|rab effector MyRIP|slp homolog lacking C2 domains c|synaptotagmin-like protein homologue lacking C2 domains-c|synaptotagmin-like protein lacking C2 domains C |
| Swissprots | Q9Y3V4 G3XAI8 Q32M42 Q32M41 B3KWM3 Q8IUF5 Q8NFW9 B7Z2H1 Q569F7 B3KWW4 B7Z9V3 |
| Accessions | EAW64595 EAW64596 Q8NFW9 AB083783 BAC15555 AF396687 AAM43954 AK125334 BAG54185 AK126013 BAG54276 AK294714 BAH11857 AK310972 AK312412 AK316068 BAH14439 AL050090 CAB43262 BC092512 AAH92512 BC109311 AAI09312 BC109312 AAI09313 CF138044 DN999201 XM_011533575 XP_011531877 NM_001284423 NP_001271352 NM_001284424 NP_001271353 NM_001284425 NP_001271354 NM_001284426 NP_001271355 NM_015460 NP_056275 NR_104316 |
| Function | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments (By similarity). {ECO:0000250}. |
| Tissue Specificity | Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis. |
Slac2-c CRISPR/Cas9 KO Plasmid (h) - sc-409488 from Santa Cruz Biotechnology
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Slac2-c HDR Plasmid (h) - sc-409488-HDR from Santa Cruz Biotechnology
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Slac2-c Double Nickase Plasmid (h) - sc-409488-NIC from Santa Cruz Biotechnology
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Slac2-c Double Nickase Plasmid (h2) - sc-409488-NIC-2 from Santa Cruz Biotechnology
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Slac2-c CRISPR Activation Plasmid (h) - sc-409488-ACT from Santa Cruz Biotechnology
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Slac2-c CRISPR Activation Plasmid (h2) - sc-409488-ACT-2 from Santa Cruz Biotechnology
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Slac2-c Lentiviral Activation Particles (h) - sc-409488-LAC from Santa Cruz Biotechnology
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Slac2-c Lentiviral Activation Particles (h2) - sc-409488-LAC-2 from Santa Cruz Biotechnology
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Slac2-c siRNA (h) - sc-63038 from Santa Cruz Biotechnology
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Slac2-c shRNA Plasmid (h) - sc-63038-SH from Santa Cruz Biotechnology
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Slac2-c shRNA (h) Lentiviral Particles - sc-63038-V from Santa Cruz Biotechnology
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MYRIP RNAi - H00025924-R01 from Novus Biologicals
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MISSION® esiRNA - EHU021351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14883 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14883 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11052 from Sigma-Aldrich
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MYRIP siRNA (Human) - CRH8591 from Cohesion Biosciences
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shRNA set against Human MYRIP (NM_015460.2) - SHH348524 from Creative biogene
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shRNA set against Human MYRIP(NM_015460.2) - SHH214031 from Creative biogene
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Human MYRIP siRNA - orb269093 from Biorbyt
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MYRIP shRNA Plasmid (Human) - CHH8591 from Cohesion Biosciences
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MYRIP miRNA 3'UTR clone - MiUTR1H-06609 from Creative biogene
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