SMARCA4

Gene Symbol SMARCA4
Entrez Gene 6597
Alt Symbol BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b
Species Human
Gene Type protein-coding
Description SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Other Description ATP-dependent helicase SMARCA4|BRG1-associated factor 190A|BRM/SWI2-related gene 1|SNF2-beta|SNF2-like 4|brahma protein-like 1|global transcription activator homologous sequence|homeotic gene regulator|mitotic growth and transcription activator|nuclear protein GRB1|protein BRG-1|protein brahma homolog 1|sucrose nonfermenting-like 4|transcription activator BRG1
Swissprots B1A8Z5 B1A8Z4 B1A8Z7 O95052 P51532 E9PBR8 B1A8Z6 Q9HBD3
Accessions AAC97986 AAC97987 AAG24789 AAG24790 EAW84162 EAW84163 EAW84164 EAW84165 EAW84166 EAW84167 P51532 AB209313 BAD92550 AI695800 AK026573 AK055168 BAG51479 AK097105 AK290033 BAF82722 AK299761 BAG61650 AK303352 BAG64413 AK308763 BC007302 BC035916 BC136644 AAI36645 BC139917 AAI39918 BC139924 AAI39925 BC150298 AAI50299 BC151849 AAI51850 BG396607 BQ009907 CT005139 D26156 BAA05143 EU430756 ACA09750 EU430757 ACA09751 EU430758 ACA09752 EU430759 ACA09753 U29175 AAB40977 XM_005260028 XP_005260085 XM_005260030 XP_005260087 XM_005260031 XP_005260088 XM_005260032 XP_005260089 XM_005260033 XP_005260090 XM_005260034 XP_005260091 XM_005260035 XP_005260092 XM_006722845 XP_006722908 XM_006722846 XP_006722909 XM_006722847 XP_006722910 XM_011528198 XP_011526500 NM_001128844 NP_001122316 NM_001128845 NP_001122317 NM_001128846 NP_001122318 NM_001128847 NP_001122319 NM_001128848 NP_001122320 NM_001128849 NP_001122321 NM_003072 NP_003063
Function Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chroma
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549, ECO:0000269|PubMed:20418909}.
Tissue Specificity Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). {ECO:0000269|PubMed:20418909}.

Rabbit anti-BRG1/SMARCA4 Antibody, Affinity Purified - PLA0146 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-BRG1/SMARCA4 Antibody, Affinity Purified: <B>Cat. No. PLA0146</B>: Detection of Human and Mouse BRG1/SMARCA4 by Immunohistochemistry. Sample: FFPE section of Human breast carcinoma (left) and Mouse colon carcinoma CT26. Antibody: Affinity purified Rabbit Anti-BRG1/SMARCA4 (<B>Cat. No. PLA0146</B>) used at a dilution of 1:500 (0.4 μg/mL) and 1:250 (0.8 μg/mL). Detection: DAB.

Goat anti-BRG1/SMARCA4 Antibody, Affinity Purified - PLA0301 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Transcription activator BRG1 (SMARCA4), Human, ELISA Kit - CSB-EL021801HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, ELISA Kit - MBS909083 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human SMARCA4 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 25 pg/ml -1600 pg/ml.

Human Transcription activator BRG1(SMARCA4) ELISA kit - CSB-EL021801HU from Cusabio

Category ELISA Kit
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

Human Transcription activator BRG1 (SMARCA4) ELISA Kit - EKC35823 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

Human SMARCA4 ELISA Kit - E037056 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human SMARCA4 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the

anti-BRG1 antibody - ARG54016 from Arigo Biolaboratories

Category ELISA Kit

anti-BRG1 antibody - ARG54166 from Arigo Biolaboratories

Category ELISA Kit

anti-Brg1 antibody [BRG-01] - ARG62694 from Arigo Biolaboratories

Category ELISA Kit

SMARCA4 ELISA Kit (Human) (OKCA01549) - OKCA01549 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 6.25 pg/mL
Range 25 - 1,600 pg/mL

Human SMARCA4 ELISA Kit - orb405428 from Biorbyt

Category ELISA Kit
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml
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