SMARCA4

Gene Symbol	SMARCA4
Entrez Gene	6597
Alt Symbol	BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b
Species	Human
Gene Type	protein-coding
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Other Description	ATP-dependent helicase SMARCA4|BRG1-associated factor 190A|BRM/SWI2-related gene 1|SNF2-beta|SNF2-like 4|brahma protein-like 1|global transcription activator homologous sequence|homeotic gene regulator|mitotic growth and transcription activator|nuclear protein GRB1|protein BRG-1|protein brahma homolog 1|sucrose nonfermenting-like 4|transcription activator BRG1
Swissprots	B1A8Z5 B1A8Z4 B1A8Z7 O95052 P51532 E9PBR8 B1A8Z6 Q9HBD3
Accessions	AAC97986 AAC97987 AAG24789 AAG24790 EAW84162 EAW84163 EAW84164 EAW84165 EAW84166 EAW84167 P51532 AB209313 BAD92550 AI695800 AK026573 AK055168 BAG51479 AK097105 AK290033 BAF82722 AK299761 BAG61650 AK303352 BAG64413 AK308763 BC007302 BC035916 BC136644 AAI36645 BC139917 AAI39918 BC139924 AAI39925 BC150298 AAI50299 BC151849 AAI51850 BG396607 BQ009907 CT005139 D26156 BAA05143 EU430756 ACA09750 EU430757 ACA09751 EU430758 ACA09752 EU430759 ACA09753 U29175 AAB40977 XM_005260028 XP_005260085 XM_005260030 XP_005260087 XM_005260031 XP_005260088 XM_005260032 XP_005260089 XM_005260033 XP_005260090 XM_005260034 XP_005260091 XM_005260035 XP_005260092 XM_006722845 XP_006722908 XM_006722846 XP_006722909 XM_006722847 XP_006722910 XM_011528198 XP_011526500 NM_001128844 NP_001122316 NM_001128845 NP_001122317 NM_001128846 NP_001122318 NM_001128847 NP_001122319 NM_001128848 NP_001122320 NM_001128849 NP_001122321 NM_003072 NP_003063
Function	Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chroma
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549, ECO:0000269|PubMed:20418909}.
Tissue Specificity	Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). {ECO:0000269|PubMed:20418909}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BRG1 full length protein - ab82237 from Abcam Category Protein Prices $315.00 Sizes 5 µg Source Baculovirus Species Human

Human BRG1 (mutated K798) full length protein - ab82091 from Abcam Category Protein Prices $297.00 Sizes 5 µg Source Baculovirus Species Human

Human BRG1 peptide - ab13736 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human BRG1 protein fragment - ab152693 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human BRG1 protein fragment - ab198137 from Abcam Category Protein Prices $837.00 Sizes 100 µg Source E. coli Species Human

Human BRG1 protein fragment - ab176931 from Abcam Category Protein Prices $248.00 Sizes 20 µg Source E. coli Species Human

Human BRG1 protein fragment - ab183264 from Abcam Category Protein Prices $301.00 Sizes 100 µg Source E. coli Species Human

S. cerevisiae SWI2 / SNF2 peptide - ab17219 from Abcam Category Peptide

SMARCA4 / BRG1 Antibody Blocking Peptide - LS-E25714 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Brg1 Partial Recombinant Protein - H00006597-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SMARCA4 protein (His tag) - 80R-3932 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

SMARCA4 (362-549, His-tag) - AR51619PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SMARCA4 (362-549, His-tag) - AR51619PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SMARCA4 / BRG1 - H00006597-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMARCA4 / BRG1 - H00006597-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMARCA4 Peptide - 7749P from ProSci Category Peptide Species Human

SMARCA4 fusion protein - Ag16256 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SMARCA4 fusion protein - Ag17718 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant SMARCA4 / BRG1 (1448-1569) protein - 31401 from ActiveMotif Category Protein Prices $395.00 Sizes 100 μg Source E. coli Species Human

Recombinant SMARCA4 / BRG1 (1448-1569), GST-tag - 31482 from ActiveMotif Prices $395.00 Sizes 100 µg Source E. coli Species Human

Recombinant Human SMARCA4 - SMARCA4-1019H from Creative Biomart Category Protein Source Sf9 insect cells.

Recombinant Human SMARCA4, His-tagged - SMARCA4-27675TH from Creative Biomart Category Protein Source Baculovirus-insect cell Species Human

Recombinant Human SMARCA4 - SMARCA4-27676TH from Creative Biomart Category Protein

Recombinant Human SMARCA4, His-tagged - SMARCA4-8471H from Creative Biomart Category Protein Source Baculovirus-insect cell Species Human

Recombinant Human SMARCA4, GST-tagged - SMARCA4-1910H from Creative Biomart Category Protein Source E. coli Species Human

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