| Gene Symbol | SMARCA4 |
|---|---|
| Entrez Gene | 6597 |
| Alt Symbol | BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b |
| Species | Human |
| Gene Type | protein-coding |
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| Other Description | ATP-dependent helicase SMARCA4|BRG1-associated factor 190A|BRM/SWI2-related gene 1|SNF2-beta|SNF2-like 4|brahma protein-like 1|global transcription activator homologous sequence|homeotic gene regulator|mitotic growth and transcription activator|nuclear protein GRB1|protein BRG-1|protein brahma homolog 1|sucrose nonfermenting-like 4|transcription activator BRG1 |
| Swissprots | B1A8Z5 B1A8Z4 B1A8Z7 O95052 P51532 E9PBR8 B1A8Z6 Q9HBD3 |
| Accessions | AAC97986 AAC97987 AAG24789 AAG24790 EAW84162 EAW84163 EAW84164 EAW84165 EAW84166 EAW84167 P51532 AB209313 BAD92550 AI695800 AK026573 AK055168 BAG51479 AK097105 AK290033 BAF82722 AK299761 BAG61650 AK303352 BAG64413 AK308763 BC007302 BC035916 BC136644 AAI36645 BC139917 AAI39918 BC139924 AAI39925 BC150298 AAI50299 BC151849 AAI51850 BG396607 BQ009907 CT005139 D26156 BAA05143 EU430756 ACA09750 EU430757 ACA09751 EU430758 ACA09752 EU430759 ACA09753 U29175 AAB40977 XM_005260028 XP_005260085 XM_005260030 XP_005260087 XM_005260031 XP_005260088 XM_005260032 XP_005260089 XM_005260033 XP_005260090 XM_005260034 XP_005260091 XM_005260035 XP_005260092 XM_006722845 XP_006722908 XM_006722846 XP_006722909 XM_006722847 XP_006722910 XM_011528198 XP_011526500 NM_001128844 NP_001122316 NM_001128845 NP_001122317 NM_001128846 NP_001122318 NM_001128847 NP_001122319 NM_001128848 NP_001122320 NM_001128849 NP_001122321 NM_003072 NP_003063 |
| Function | Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chroma |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549, ECO:0000269|PubMed:20418909}. |
| Tissue Specificity | Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). {ECO:0000269|PubMed:20418909}. |
Brg-1 CRISPR/Cas9 KO Plasmid (h) - sc-400168 from Santa Cruz Biotechnology
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Brg-1 HDR Plasmid (h) - sc-400168-HDR from Santa Cruz Biotechnology
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Brg-1 Double Nickase Plasmid (h) - sc-400168-NIC from Santa Cruz Biotechnology
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Brg-1 Double Nickase Plasmid (h2) - sc-400168-NIC-2 from Santa Cruz Biotechnology
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Brg-1 CRISPR Activation Plasmid (h) - sc-400168-ACT from Santa Cruz Biotechnology
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Brg-1 CRISPR Activation Plasmid (h2) - sc-400168-ACT-2 from Santa Cruz Biotechnology
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Brg-1 Lentiviral Activation Particles (h) - sc-400168-LAC from Santa Cruz Biotechnology
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Brg-1 Lentiviral Activation Particles (h2) - sc-400168-LAC-2 from Santa Cruz Biotechnology
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Brg-1 siRNA (h) - sc-29827 from Santa Cruz Biotechnology
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Brg-1 shRNA Plasmid (h) - sc-29827-SH from Santa Cruz Biotechnology
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Brg-1 shRNA (h) Lentiviral Particles - sc-29827-V from Santa Cruz Biotechnology
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Brg-1 siRNA (h2) - sc-44287 from Santa Cruz Biotechnology
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Brg-1 shRNA Plasmid (h2) - sc-44287-SH from Santa Cruz Biotechnology
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Brg-1 shRNA (h2) Lentiviral Particles - sc-44287-V from Santa Cruz Biotechnology
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Brg1 RNAi - H00006597-R01 from Novus Biologicals
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MISSION® esiRNA - EHU076601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19762 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19762 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03841 from Sigma-Aldrich
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SMARCA4 siRNA (Human) - CRH4481 from Cohesion Biosciences
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SMARCA4 - MBS8235177 from MyBioSource
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shRNA set against Human Smarca4 (NM_003072.3) - SHH413100 from Creative biogene
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SMARCA4 shRNA Plasmid (Human) - CHH4481 from Cohesion Biosciences
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SMARCA4 miRNA 3'UTR clone - MiUTR3H-05808 from Creative biogene
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SMARCA4 miRNA 3'UTR clone - MiUTR3H-05809 from Creative biogene
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