DROSHA

Gene Symbol	DROSHA
Entrez Gene	29102
Alt Symbol	ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
Species	Human
Gene Type	protein-coding
Description	drosha, ribonuclease type III
Other Description	RNase III|drosha, double-stranded RNA-specific endoribonuclease|nuclear RNase III Drosha|p241|protein Drosha|putative protein p241 which interacts with transcription factor Sp1|putative ribonuclease III|ribonuclease 3|ribonuclease III, nuclear|ribonuclease type III, nuclear
Swissprots	Q9Y4Y0 Q7Z5V2 Q86YH0 Q9Y2V9 E7EMP9 Q9NRR4 Q9NW73
Accessions	CBM42910 CBV35643 EAX10767 EAX10768 EAX10769 EAX10770 Q9NRR4 AA917625 AB209501 BAD92738 AF116910 AAD29637 AF189011 AAF80558 AJ242976 CAB45133 AK001121 BAA91511 AK026563 AK308093 BC024261 BC041162 AAH41162 BC054003 AAH54003 BX647724 DB065470 XM_005248291 XP_005248348 XM_005248292 XP_005248349 XM_005248293 XP_005248350 XM_005248294 XP_005248351 XM_011514033 XP_011512335 NM_001100412 NP_001093882 NM_013235 NP_037367
Function	Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994}.
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10948199}.
Top Pathways	Ribosome biogenesis in eukaryotes, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DROSHA / RNASEN ELISA Kit (Sandwich ELISA) - LS-F7638 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.126 ng/ml Range 0.313-20 ng/ml

Ribonuclease III, Nuclear (RNASEN), Human, ELISA Kit - SED163Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.126ng/mL Range 0.312-20ng/mL

Ribonuclease III, Nuclear, RNASEN, Human, ELISA Kit - E-EL-H2412 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Ribonuclease III, Nuclear, RNASEN, Rabbit, ELISA Kit - E-EL-RB0734 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ribonuclease III, Nuclear, RNASEN, Chicken, ELISA Kit - E-EL-Ch2002 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ribonuclease III, Nuclear, RNASEN, Porcine, ELISA Kit - E-EL-P1277 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ribonuclease III, Nuclear, RNASEN, Sheep, ELISA Kit - E-EL-S0496 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Ribonuclease III, Nuclear, RNASEN, Guinea Pig, ELISA Kit - E-EL-GP0483 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ribonuclease III, Nuclear, RNASEN, Monkey, ELISA Kit - E-EL-MK1765 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human RNASEN(Ribonuclease Ⅲ, Nuclear) ELISA Kit - E-EL-H2412 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human RNASEN (Ribonuclease Ⅲ, Nuclear) CLIA Kit - E-CL-H1414 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

Ribonuclease III, Nuclear, ELISA Kit - MBS054805 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribonuclease III, Nuclear, ELISA Kit - MBS048737 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribonuclease III, Nuclear, ELISA Kit - MBS057699 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribonuclease III, Nuclear, ELISA Kit - MBS050546 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribonuclease III, Nuclear, ELISA Kit - MBS052163 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribonuclease III, Nuclear, ELISA Kit - MBS062659 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribonuclease III, Nuclear, ELISA Kit - MBS053198 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribonuclease III, Nuclear (RNASEN), ELISA Kit - MBS2023332 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.126ng/mL. Range 0.313-20ng/mL

RNASEN, ELISA Kit - MBS2513666 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

RNASEN, ELISA Kit - MBS2506831 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

RNASEN, ELISA Kit - MBS2503561 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

RNASEN, ELISA Kit - MBS2509995 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

RNASEN, ELISA Kit - MBS2507948 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

RNASEN, ELISA Kit - MBS2504878 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

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