DROSHA

Gene Symbol	DROSHA
Entrez Gene	29102
Alt Symbol	ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
Species	Human
Gene Type	protein-coding
Description	drosha, ribonuclease type III
Other Description	RNase III|drosha, double-stranded RNA-specific endoribonuclease|nuclear RNase III Drosha|p241|protein Drosha|putative protein p241 which interacts with transcription factor Sp1|putative ribonuclease III|ribonuclease 3|ribonuclease III, nuclear|ribonuclease type III, nuclear
Swissprots	Q9Y4Y0 Q7Z5V2 Q86YH0 Q9Y2V9 E7EMP9 Q9NRR4 Q9NW73
Accessions	CBM42910 CBV35643 EAX10767 EAX10768 EAX10769 EAX10770 Q9NRR4 AA917625 AB209501 BAD92738 AF116910 AAD29637 AF189011 AAF80558 AJ242976 CAB45133 AK001121 BAA91511 AK026563 AK308093 BC024261 BC041162 AAH41162 BC054003 AAH54003 BX647724 DB065470 XM_005248291 XP_005248348 XM_005248292 XP_005248349 XM_005248293 XP_005248350 XM_005248294 XP_005248351 XM_011514033 XP_011512335 NM_001100412 NP_001093882 NM_013235 NP_037367
Function	Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994}.
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10948199}.
Top Pathways	Ribosome biogenesis in eukaryotes, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Drosha peptide - ab12307 from Abcam Category Peptide Source CHO

Human Drosha protein fragment - ab94010 from Abcam Category Protein Source E. coli Species Human

DROSHA / RNASEN Antibody Blocking Peptide - LS-E6259 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DROSHA / RNASEN Antibody Blocking Peptide - LS-E14923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DROSHA / RNASEN Antibody Blocking Peptide - LS-E26216 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Drosha Protein - H00029102-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Drosha blocking peptide - GTX89198-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

RNASEN Blocking Peptide - 33R-1038 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DROSHA Blocking Peptide - abx063833 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Human RNASEN Protein - abx068923 from Abbexa Category Protein Source E.coli Species Human

Drosha Peptide - AC21-1047-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNASEN - H00029102-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNASEN - H00029102-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Ribonuclease III, Nuclear (RNASEN) - RPD163Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

DROSHA Blocking Peptide - CBP2639 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Drosha Peptide - BS60422P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Ribonuclease III, Nuclear (RNASEN) - RPD163Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Ribonuclease 3(DROSHA) ,partial - CSB-YP889096HU CSB-EP889096HU CSB-BP889096HU CSB-MP889096HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Ribonuclease III, Nuclear (RNASEN) - RPU143650 from Biomatik Category Protein Prices $242.00, $484.00, $726.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

DROSHA Peptide - abx164640 from Abbexa Category Peptide Species Human

DROSHA Peptide, Human - M34GP04552H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Ribonuclease III, Nuclear (RNASEN) - RPU43650 from Biomatik Category Protein Prices $194.00, $396.00, $605.00, $721.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

RNASEN Recombinant Protein (OPCD06723) - OPCD06723 from Aviva Systems Biology Category Protein Source E.coli Species Human

Drosha Recombinant Protein Antigen - NBP2-58421PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Ribonuclease 3 (DROSHA), partial, Recombinant Protein - MBS1402993 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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