Gene Symbol | SF3B6 |
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Entrez Gene | 51639 |
Alt Symbol | CGI-110, HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a |
Species | Human |
Gene Type | protein-coding |
Description | splicing factor 3b, subunit 6, 14kDa |
Other Description | SF3b 14 kDa subunit|pre mRNA branch site protein p14|pre-mRNA branch site protein p14|spliceosome-associated protein, 14 kDa subunit|spliceosome-associated protein, 14-kDa|splicing factor 3B subunit 6|splicing factor 3B, 14 kDa subunit |
Swissprots | Q9Y3B4 Q53TM1 |
Accessions | AAY14664 EAX00767 Q9Y3B4 AF151868 AAD34105 AF161523 AAF29138 AF184213 AAG09698 AF401310 AAK94041 AK000621 AK311118 AK311908 BAG34849 BC015463 AAH15463 BG200650 JF432474 ADZ15691 NM_016047 NP_057131 |
Function | Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. {ECO:0000269|PubMed:16432215}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | Spliceosome |
SAP 14 CRISPR/Cas9 KO Plasmid (h) - sc-412229 from Santa Cruz Biotechnology
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SAP 14 HDR Plasmid (h) - sc-412229-HDR from Santa Cruz Biotechnology
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SAP 14 Double Nickase Plasmid (h) - sc-412229-NIC from Santa Cruz Biotechnology
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SAP 14 Double Nickase Plasmid (h2) - sc-412229-NIC-2 from Santa Cruz Biotechnology
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SAP 14 CRISPR Activation Plasmid (h) - sc-412229-ACT from Santa Cruz Biotechnology
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SAP 14 CRISPR Activation Plasmid (h2) - sc-412229-ACT-2 from Santa Cruz Biotechnology
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SAP 14 Lentiviral Activation Particles (h) - sc-412229-LAC from Santa Cruz Biotechnology
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SAP 14 Lentiviral Activation Particles (h2) - sc-412229-LAC-2 from Santa Cruz Biotechnology
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SAP 14 siRNA (h) - sc-94634 from Santa Cruz Biotechnology
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SAP 14 shRNA Plasmid (h) - sc-94634-SH from Santa Cruz Biotechnology
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SAP 14 shRNA (h) Lentiviral Particles - sc-94634-V from Santa Cruz Biotechnology
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SF3B14 RNAi - H00051639-R01 from Novus Biologicals
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MISSION® esiRNA - EHU019761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19186 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19186 from Sigma-Aldrich
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SF3B6 siRNA (Human) - CRH9873 from Cohesion Biosciences
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SF3B6 - MBS8212664 from MyBioSource
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shRNA set against Human SF3B14 (NM_016047.3) - SHH405820 from Creative biogene
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Human SF3B6 siRNA - orb270375 from Biorbyt
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SF3B6 shRNA Plasmid (Human) - CHH9873 from Cohesion Biosciences
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SF3B14 miRNA 3'UTR clone - MiUTR1H-09325 from Creative biogene
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