| Gene Symbol |
SEMA3E
|
| Entrez Gene |
9723
|
| Alt Symbol |
M-SEMAH, M-SemaK, SEMAH, coll-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
|
| Other Description |
semaphorin-3E
|
| Swissprots |
Q75M97 B4E1P1 Q75M94 O15041
|
| Accessions |
AAC69513 AAS07487 AAS07488 CAI84574 EAL24186 EAW76983 O15041 AB002329 BAA20789 AK297209 BAG59693 AK303925 BAG64853 BC140706 AAI40707 BC144338 AAI44339 BC152458 AAI52459 DA722912 DB215551 XM_011516715 XP_011515017 NM_001178129 NP_001171600 NM_012431 NP_036563
|
| Function |
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Top Pathways |
Axon guidance
|
![Western Blot: SEMA3E Overexpression Lysate (Adult Normal) [NBP2-07444] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SEMA3E.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7186_SEMA3E%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07444-img0001.jpg)