Gene Symbol | SEMA3E |
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Entrez Gene | 9723 |
Alt Symbol | M-SEMAH, M-SemaK, SEMAH, coll-5 |
Species | Human |
Gene Type | protein-coding |
Description | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E |
Other Description | semaphorin-3E |
Swissprots | Q75M97 B4E1P1 Q75M94 O15041 |
Accessions | AAC69513 AAS07487 AAS07488 CAI84574 EAL24186 EAW76983 O15041 AB002329 BAA20789 AK297209 BAG59693 AK303925 BAG64853 BC140706 AAI40707 BC144338 AAI44339 BC152458 AAI52459 DA722912 DB215551 XM_011516715 XP_011515017 NM_001178129 NP_001171600 NM_012431 NP_036563 |
Function | Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000250}. |
Top Pathways | Axon guidance |
SEMA3E CRISPR/Cas9 KO Plasmid (h) - sc-404797 from Santa Cruz Biotechnology
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SEMA3E HDR Plasmid (h) - sc-404797-HDR from Santa Cruz Biotechnology
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SEMA3E Double Nickase Plasmid (h) - sc-404797-NIC from Santa Cruz Biotechnology
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SEMA3E Double Nickase Plasmid (h2) - sc-404797-NIC-2 from Santa Cruz Biotechnology
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SEMA3E CRISPR Activation Plasmid (h) - sc-404797-ACT from Santa Cruz Biotechnology
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SEMA3E CRISPR Activation Plasmid (h2) - sc-404797-ACT-2 from Santa Cruz Biotechnology
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SEMA3E Lentiviral Activation Particles (h) - sc-404797-LAC from Santa Cruz Biotechnology
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SEMA3E Lentiviral Activation Particles (h2) - sc-404797-LAC-2 from Santa Cruz Biotechnology
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SEMA3E siRNA (h) - sc-61520 from Santa Cruz Biotechnology
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SEMA3E shRNA Plasmid (h) - sc-61520-SH from Santa Cruz Biotechnology
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SEMA3E shRNA (h) Lentiviral Particles - sc-61520-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU027181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19067 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19067 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14178 from Sigma-Aldrich
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SEMA3E siRNA (Human) - CRH6491 from Cohesion Biosciences
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Semaphorin 3E RNAi - H00009723-R02 from Novus Biologicals
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SEMA3E - MBS8201775 from MyBioSource
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shRNA set against Human Sema3e (NM_012431.2) - SHH404232 from Creative biogene
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Human SEMA3E siRNA - orb266993 from Biorbyt
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SEMA3E shRNA Plasmid (Human) - CHH6491 from Cohesion Biosciences
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SEMA3E miRNA 3'UTR clone - MiUTR4H-TG07904 from Creative biogene
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