Gene Symbol | AKR7A3 |
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Entrez Gene | 22977 |
Alt Symbol | AFAR2 |
Species | Human |
Gene Type | protein-coding |
Description | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) |
Other Description | AFB1 aldehyde reductase 2|AFB1-AR 2|aflatoxin B1 aldehyde reductase 2|aflatoxin B1 aldehyde reductase member 3 |
Swissprots | Q9NUC3 O95154 Q8N5V6 Q8TAX1 Q86SR4 Q8IVN6 |
Accessions | EAW94878 EAW94879 O95154 AA844782 AF040639 AAD02195 AJ271799 CAC81076 BC025709 AAH25709 BC031562 AAH31562 BC042420 AAH42420 BG747063 BM855386 BM920315 EU176235 ABW03686 EU176541 ABW03342 EU831806 ACE87324 EU831883 ACE86642 XM_011541046 XP_011539348 XM_011541047 XP_011539349 NM_012067 NP_036199 |
Function | Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:18416522}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. {ECO:0000269|PubMed:12879023, ECO:0000269|PubMed:18416522}. |
Top Pathways | Metabolism of xenobiotics by cytochrome P450 |
Active human AKR7A3 full length protein - ab168031 from Abcam
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Active human AKR7A3 full length protein - ab116489 from Abcam
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Human AKR7A3 full length protein - ab93635 from Abcam
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AKR7A3 Antibody Blocking Peptide - LS-E19765 from LifeSpan Bioscience
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Recombinant Human AKR7A3 Protein - NBP1-40394 from Novus Biologicals
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AKR7A3 Recombinant Protein - H00022977-P01 from Novus Biologicals
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AKR7A3 Recombinant Protein - P3497 from Novus Biologicals
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AKR7A3 Protein (OPPA01842) - OPPA01842 from Aviva Systems Biology
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Human AKR7A3 protein - orb90025 from Biorbyt
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AKR7A3 Blocking Peptide - 33R-9513 from Fitzgerald
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AKR7A3 protein (His tag) - 80R-1253 from Fitzgerald
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AKR7A3 / AFAR2 (1-331, His-tag) - AR09375PU-L from Acris Antibodies
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AKR7A3 / AFAR2 (1-331, His-tag) - AR09375PU-N from Acris Antibodies
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AKR7A3 / AFAR2 - H00022977-P01-10 from Acris Antibodies
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AKR7A3 / AFAR2 - H00022977-P01-25 from Acris Antibodies
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AKR7A3 / AFAR2 - P3497 from Acris Antibodies
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AKR7A3, 1-331aa, Human, His tag, E. coli - 01-1780-A3 from ARP American Research Products
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AKR7A3 fusion protein - Ag3991 from Proteintech Group
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AKR7A3 Human - ENPS-491 from NeoScientific
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Recombinant Human AKR7A3 - BP000864-ENZ-484 from Syd Labs
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AKR7A3, 1-331aa, Recombinant Protein - GWB-P1562B from Genway Biotech
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Recombinant Human AKR7A3, His-tagged - AKR7A3-26149TH from Creative Biomart
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Recombinant Human AKR7A3, His-tagged - AKR7A3-26727TH from Creative Biomart
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Recombinant Human AKR7A3, His-tagged - AKR7A3-1932H from Creative Biomart
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Recombinant Human AKR7A3, GST-tagged - AKR7A3-9538H from Creative Biomart
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