RECK

Gene Symbol RECK
Entrez Gene 8434
Alt Symbol ST15
Species Human
Gene Type protein-coding
Description reversion-inducing-cysteine-rich protein with kazal motifs
Other Description membrane-anchored glycoprotein (metastasis and invasion)|reversion-inducing cysteine-rich protein with Kazal motifs|suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)|suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)|suppressor of tumorigenicity 15 protein
Swissprots O95980 Q8WX37 B2RNS1 Q5W0K6
Accessions EAW58318 EAW58319 O95980 AK022897 AK292653 BAF85342 AK315073 BAG37543 BC032240 BC050306 BC060806 AAH60806 BC137093 AAI37094 BX648668 D50406 BAA34060 EF139848 JQ756320 XM_011518053 XP_011516355 NM_021111 NP_066934
Function Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
Top Pathways MicroRNAs in cancer

RECK (D8C7) Rabbit mAb - 3433 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8C7
Western blot analysis of extracts from various cell lines using RECK (D8C7) Rabbit mAb.

RECK (G-4) - sc-373929 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RECK (G-4): sc-373929. Western blot analysis of RECK expression in WI 38 whole cell lysate.

RECK (F-20) - sc-27116 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RECK (H-300) - sc-28918 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RECK (H-300): sc-28918. Western blot analysis of RECK expression in AT-3 whole cell lysate.

RECK (C-16) - sc-9687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RECK (C-16): sc-9687. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

RECK (28) - sc-136270 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
RECK (28): sc-136270. Western blot analysis of RECK expression in WI-38 whole cell lysate.

Anti-RECK Antibody (aa430-456, AP) - LS-C268030 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa430-456, APC) - LS-C268032 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa430-456, Biotin) - LS-C268033 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa430-456, FITC) - LS-C268034 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa430-456, Azide-free, HRP) - LS-C285021 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa430-456, PE) - LS-C285022 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa1-207) - LS-C311823 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa436-465) - LS-C324602 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RECK Antibody (aa580-629) - LS-C145245 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RECK antibody LS-C145245 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml.

Anti-RECK Antibody (clone 32C10A) - LS-C179295 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 32C10A

Anti-RECK Antibody - LS-C331109 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of MCF7 cells tissue, using RECK antibody.

Anti-RECK Antibody (aa430-456) - LS-C162528 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with RECK Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

RECK Antibody [Unconjugated] - AF1734 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human liver tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human RECK Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1734) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for RECK at approximately 130 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

RECK Antibody - H00008434-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RECK Antibody [H00008434-B01P] - Analysis of RECK expression in 293.

RECK Antibody - H00008434-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: RECK Antibody [H00008434-B01] - analysis of RECK expression in transfected 293T cell line by RECK MaxPab polyclonal antibody (B01). Lane 1: RECK transfected lysate (106.50 KDa). Lane 2: Non-transfected lysate.

RECK Antibody - H00008434-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RECK Antibody (MM0523-9G19) - NBP2-11863 from Novus Biologicals

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0523-9G19

RECK Antibody - H00008434-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RECK Antibody [Biotin] - BAF1734 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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