RECK

Gene Symbol RECK
Entrez Gene 8434
Alt Symbol ST15
Species Human
Gene Type protein-coding
Description reversion-inducing-cysteine-rich protein with kazal motifs
Other Description membrane-anchored glycoprotein (metastasis and invasion)|reversion-inducing cysteine-rich protein with Kazal motifs|suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)|suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)|suppressor of tumorigenicity 15 protein
Swissprots O95980 Q8WX37 B2RNS1 Q5W0K6
Accessions EAW58318 EAW58319 O95980 AK022897 AK292653 BAF85342 AK315073 BAG37543 BC032240 BC050306 BC060806 AAH60806 BC137093 AAI37094 BX648668 D50406 BAA34060 EF139848 JQ756320 XM_011518053 XP_011516355 NM_021111 NP_066934
Function Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
Top Pathways MicroRNAs in cancer

RECK CRISPR/Cas9 KO Plasmid (h) - sc-402440 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK HDR Plasmid (h) - sc-402440-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK Double Nickase Plasmid (h) - sc-402440-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK Double Nickase Plasmid (h2) - sc-402440-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK CRISPR Activation Plasmid (h) - sc-402440-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK CRISPR Activation Plasmid (h2) - sc-402440-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK Lentiviral Activation Particles (h) - sc-402440-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK Lentiviral Activation Particles (h2) - sc-402440-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK siRNA (h) - sc-39718 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RECK shRNA Plasmid (h) - sc-39718-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RECK shRNA (h) Lentiviral Particles - sc-39718-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU033411 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18119 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18119 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09769 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09769

RECK siRNA (Human) - CRH5524 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RECK - MBS8230740 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RECK CRISPR/Cas9 KO Plasmid (h2) - sc-402440-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RECK HDR Plasmid (h2) - sc-402440-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human RECK (NM_021111.2) - SHH391588 from Creative biogene

Category siRNA
Species Reactivities Human

Human RECK siRNA - orb266026 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RECK shRNA Plasmid (Human) - CHH5524 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RECK miRNA 3'UTR clone - MiUTR3H-07493 from Creative biogene

Species Reactivities Human
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