| Gene Symbol |
RECK
|
| Entrez Gene |
8434
|
| Alt Symbol |
ST15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
reversion-inducing-cysteine-rich protein with kazal motifs
|
| Other Description |
membrane-anchored glycoprotein (metastasis and invasion)|reversion-inducing cysteine-rich protein with Kazal motifs|suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)|suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)|suppressor of tumorigenicity 15 protein
|
| Swissprots |
O95980 Q8WX37 B2RNS1 Q5W0K6
|
| Accessions |
EAW58318 EAW58319 O95980 AK022897 AK292653 BAF85342 AK315073 BAG37543 BC032240 BC050306 BC060806 AAH60806 BC137093 AAI37094 BX648668 D50406 BAA34060 EF139848 JQ756320 XM_011518053 XP_011516355 NM_021111 NP_066934
|
| Function |
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor.
|
| Tissue Specificity |
Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
|
| Top Pathways |
MicroRNAs in cancer
|
