| Gene Symbol |
ZCCHC11
|
| Entrez Gene |
23318
|
| Alt Symbol |
PAPD3, TUT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, CCHC domain containing 11
|
| Other Description |
PAP associated domain containing 3|TUTase 4|terminal uridylyltransferase 4|zinc finger CCHC domain-containing protein 11
|
| Swissprots |
Q12764 B7Z8J5 A2RRP0 Q5TAX3 Q86XZ3 Q5TAX2 Q5TAX4 D3DQ35
|
| Accessions |
EAX06778 EAX06780 Q5TAX3 AK025698 AK095733 AK124868 AK307579 AK308427 BC012047 BC018753 BC035820 BC048301 BC131734 AAI31735 BX439159 BX648248 BX648783 BX649065 D83776 BAA12105 DA748708 R60512 XM_005270676 XP_005270733 XM_005270678 XP_005270735 XM_005270679 XP_005270736 XM_005270680 XP_005270737 XM_005270681 XP_005270738 XM_005270682 XP_005270739 XM_005270683 XP_005270740 XM_005270684 XP_005270741 XM_005270685 XP_005270742 XM_006710498 XP_006710561 XM_006710499 XP_006710562 XM_006710500 XP_006710563 XM_011541097 XP_011539399 XM_011541098 XP_011539400 XM_011541099 XP_011539401 XM_011541100 XP_011539402 XM_011541101 XP_011539403 XM_011541102 XP_011539404 NM_001009882 NM_001009881 NP_001009881 NM_015269 NP_056084
|
| Function |
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:19703396}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS.
|