ZCCHC11

Gene Symbol	ZCCHC11
Entrez Gene	23318
Alt Symbol	PAPD3, TUT4
Species	Human
Gene Type	protein-coding
Description	zinc finger, CCHC domain containing 11
Other Description	PAP associated domain containing 3|TUTase 4|terminal uridylyltransferase 4|zinc finger CCHC domain-containing protein 11
Swissprots	Q12764 B7Z8J5 A2RRP0 Q5TAX3 Q86XZ3 Q5TAX2 Q5TAX4 D3DQ35
Accessions	EAX06778 EAX06780 Q5TAX3 AK025698 AK095733 AK124868 AK307579 AK308427 BC012047 BC018753 BC035820 BC048301 BC131734 AAI31735 BX439159 BX648248 BX648783 BX649065 D83776 BAA12105 DA748708 R60512 XM_005270676 XP_005270733 XM_005270678 XP_005270735 XM_005270679 XP_005270736 XM_005270680 XP_005270737 XM_005270681 XP_005270738 XM_005270682 XP_005270739 XM_005270683 XP_005270740 XM_005270684 XP_005270741 XM_005270685 XP_005270742 XM_006710498 XP_006710561 XM_006710499 XP_006710562 XM_006710500 XP_006710563 XM_011541097 XP_011539399 XM_011541098 XP_011539400 XM_011541099 XP_011539401 XM_011541100 XP_011539402 XM_011541101 XP_011539403 XM_011541102 XP_011539404 NM_001009882 NM_001009881 NP_001009881 NM_015269 NP_056084
Function	Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:19703396}.
Subcellular Location	Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ZCH11 full length protein - ab131808 from Abcam Category Protein Source Wheat germ Species Human

Human ZCH11 peptide - ab23172 from Abcam Category Peptide Species Human

KIAA0191 / ZCCHC11 Antibody Blocking Peptide - LS-E27752 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KIAA0191 / ZCCHC11 Antibody Blocking Peptide - LS-E25205 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KIAA0191 / ZCCHC11 Antibody Blocking Peptide - LS-E21494 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ZCCHC11/TUT4 Protein - H00023318-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ZCCHC11/PAPD3 blocking peptide - GTX94119-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

ZCCHC11 Blocking Peptide - 33R-3549 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ZCH11 Peptide - AC21-0026-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ZCCHC11 - H00023318-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZCCHC11 - H00023318-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZCCHC11 Peptide - 46-610P from ProSci Category Peptide Species Human

ZCCHC11 fusion protein - Ag13661 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ZCCHC11, GST-tagged - ZCCHC11-3790H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Terminal uridylyltransferase 4(ZCCHC11) ,partial - CSB-YP719419HU CSB-EP719419HU CSB-BP719419HU CSB-MP719419HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Terminal uridylyltransferase 4 (ZCCHC11), partial, Recombinant Protein - MBS1350134 from MyBioSource Category Protein Prices $890.00, $890.00, $1,115.00, $1,115.00, $1,250.00, $1,250.00, $1,710.00, $1,710.00, $1,745.00, $2,475.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZCCHC11/PAPD3, Peptide - MBS426245 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

ZCCHC11/TUT4 Recombinant Protein Antigen - NBP1-83027PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZCCHC11/TUT4 Recombinant Protein Antigen - NBP1-83026PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZCCHC11 Peptide, Human - M34GP17729H from Creative Peptides Category Peptide Source Synthetic. Species Human

Zcchc11 Immunizing peptide - orb63226 from Biorbyt Category Peptide

Search more