ZCCHC11

Gene Symbol ZCCHC11
Entrez Gene 23318
Alt Symbol PAPD3, TUT4
Species Human
Gene Type protein-coding
Description zinc finger, CCHC domain containing 11
Other Description PAP associated domain containing 3|TUTase 4|terminal uridylyltransferase 4|zinc finger CCHC domain-containing protein 11
Swissprots Q12764 B7Z8J5 A2RRP0 Q5TAX3 Q86XZ3 Q5TAX2 Q5TAX4 D3DQ35
Accessions EAX06778 EAX06780 Q5TAX3 AK025698 AK095733 AK124868 AK307579 AK308427 BC012047 BC018753 BC035820 BC048301 BC131734 AAI31735 BX439159 BX648248 BX648783 BX649065 D83776 BAA12105 DA748708 R60512 XM_005270676 XP_005270733 XM_005270678 XP_005270735 XM_005270679 XP_005270736 XM_005270680 XP_005270737 XM_005270681 XP_005270738 XM_005270682 XP_005270739 XM_005270683 XP_005270740 XM_005270684 XP_005270741 XM_005270685 XP_005270742 XM_006710498 XP_006710561 XM_006710499 XP_006710562 XM_006710500 XP_006710563 XM_011541097 XP_011539399 XM_011541098 XP_011539400 XM_011541099 XP_011539401 XM_011541100 XP_011539402 XM_011541101 XP_011539403 XM_011541102 XP_011539404 NM_001009882 NM_001009881 NP_001009881 NM_015269 NP_056084
Function Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:19703396}.
Subcellular Location Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS.

ZCCHC11 CRISPR/Cas9 KO Plasmid (h) - sc-411714 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 HDR Plasmid (h) - sc-411714-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 Double Nickase Plasmid (h) - sc-411714-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 Double Nickase Plasmid (h2) - sc-411714-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 CRISPR Activation Plasmid (h) - sc-411714-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 CRISPR Activation Plasmid (h2) - sc-411714-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 Lentiviral Activation Particles (h) - sc-411714-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 Lentiviral Activation Particles (h2) - sc-411714-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZCCHC11 siRNA (h) - sc-88218 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZCCHC11 shRNA Plasmid (h) - sc-88218-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZCCHC11 shRNA (h) Lentiviral Particles - sc-88218-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZCCHC11/TUT4 RNAi - H00023318-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

ZCCHC11/TUT4 RNAi - H00023318-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU157521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN23113 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23113 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07230 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07230

ZCCHC11 siRNA (Human) - CRH8177 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZCCHC11/TUT4 RNAi - H00023318-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ZCCHC11 - MBS828286 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ZCCHC11 (NM_001009881.2) - SHH449588 from Creative biogene

Category siRNA
Species Reactivities Human

Human ZCCHC11 siRNA - orb268679 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZCCHC11 shRNA Plasmid (Human) - CHH8177 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ZCCHC11 miRNA 3'UTR clone - MiUTR3H-13004 from Creative biogene

Species Reactivities Human

ZCCHC11 miRNA 3'UTR clone - MiUTR3H-13005 from Creative biogene

Species Reactivities Human
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