DUSP1

Gene Symbol DUSP1
Entrez Gene 1843
Alt Symbol CL100, HVH1, MKP-1, MKP1, PTPN10
Species Human
Gene Type protein-coding
Description dual specificity phosphatase 1
Other Description MAP kinase phosphatase 1|dual specificity protein phosphatase 1|dual specificity protein phosphatase hVH1|mitogen-activated protein kinase phosphatase 1|protein-tyrosine phosphatase CL100|serine/threonine specific protein phosphatase
Swissprots Q2V508 D3DQL9 P28562
Accessions ABB96250 CAK32189 CBX47580 EAW61425 EAW61426 P28562 AA843403 AJ227912 AK298047 BAG60344 AK298658 BAG60826 AK299391 BAG61376 AK300487 BAG62202 AK304475 BAG65288 AK316321 BAH14692 BC022463 AAH22463 X68277 CAA48338 NM_004417 NP_004408
Function Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. {ECO:0000269|PubMed:8106404}.
Top Pathways MAPK signaling pathway

Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb - 2857 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 125E2
Western blot analysis of extracts from HeLa cells, treated with λ Phosphatase or ALLN, using Phospho-DUSP1/MKP1 (Ser359) (125E2) Rabbit mAb.

MKP-1 (D-3) - sc-271684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MKP-1 (D-3): sc-271684. Western blot analysis of MKP-1 expression in SW480 whole cell lysate.

MKP-1 (C-19) - sc-370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MKP-1 (C-19): sc-370. Western blot analysis of MKP-1 expression in HeLa whole cell lysate.

MKP-1 (E-6) - sc-373841 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MKP-1 (E-6): sc-373841. Western blot analysis of MKP-1 expression in non-transfected: sc-117752 (A) and mouse MKP-1 transfected: sc-121680 (B) 293T whole cell lysates.

MKP-1 (H-66) - sc-10796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MKP-1 (H-66): sc-10796. Western blot analysis of human recombinant MKP-1 fusion protein.

MKP-1 (M-18) - sc-1102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MKP-1 (M-18): sc-1102. Western blot analysis of MKP-1 expression in Hep G2 (A) and SW480 (B) whole cell lysates.

MKP-1 (V-15) - sc-1199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MKP-1 (V-15): sc-1199. Western blot analysis of MKP-1 expression in A-431 (A) and HeLa (B) whole cell lysates.

Anti-DUSP1 (phospho S359) antibody - ab63548 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab36548 at 1/50-1/100 dilution staining human lung carcinoma tissue, without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-DUSP1 antibody - ab1351 from Abcam

Prices $391.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Endogenous DUSP1 staining (2µg/ml) of HeLa lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence

Anti-DUSP1 antibody - ab61201 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DUSP1 antibody (ab61201) at 1/500 dilutionLane 1 : Jurkat cell extractsLane 2 : Jurkat cell extracts with immunising peptide

Anti-DUSP1 antibody - ab138265 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DUSP1 antibody (ab138265) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-DUSP1 antibody - ab37493 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DUSP1 antibody (ab37493) + HEK 293 cell lysate.

Anti-DUSP1 / MKP1 Antibody (N-Terminus, AP) - LS-C225194 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody (N-Terminus, Biotin) - LS-C225195 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody (phospho-Ser359) - LS-C199263 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma, using MKP1 (Phospho-Ser359) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-DUSP1 / MKP1 Antibody (N-Terminus, FITC) - LS-C225196 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody (N-Terminus, Azide-free, HRP) - LS-C225197 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody (N-Terminus, PE) - LS-C225198 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody (clone 4H7) - LS-C197088 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H7
Detection limit for recombinant GST tagged DUSP1 is 0.3 ng/ml as a capture antibody.

Anti-DUSP1 / MKP1 Antibody (N-Terminus, APC) - LS-C227140 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MKP-1 / DUSP1 Antibody (aa305-367) - LS-C311439 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MKP-1 / DUSP1 Antibody (aa165-343) - LS-C311500 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody (N-Terminus) - LS-C327227 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody - LS-C341251 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DUSP1 / MKP1 Antibody (aa318-367) - LS-C117981 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using MKP1 (Ab-359) Antibody. The picture on the right is treated with the synthesized peptide.
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