| Gene Symbol |
DUSP1
|
| Entrez Gene |
1843
|
| Alt Symbol |
CL100, HVH1, MKP-1, MKP1, PTPN10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual specificity phosphatase 1
|
| Other Description |
MAP kinase phosphatase 1|dual specificity protein phosphatase 1|dual specificity protein phosphatase hVH1|mitogen-activated protein kinase phosphatase 1|protein-tyrosine phosphatase CL100|serine/threonine specific protein phosphatase
|
| Swissprots |
Q2V508 D3DQL9 P28562
|
| Accessions |
ABB96250 CAK32189 CBX47580 EAW61425 EAW61426 P28562 AA843403 AJ227912 AK298047 BAG60344 AK298658 BAG60826 AK299391 BAG61376 AK300487 BAG62202 AK304475 BAG65288 AK316321 BAH14692 BC022463 AAH22463 X68277 CAA48338 NM_004417 NP_004408
|
| Function |
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. {ECO:0000269|PubMed:8106404}.
|
| Top Pathways |
MAPK signaling pathway
|