| Gene Symbol |
KAT8
|
| Entrez Gene |
84148
|
| Alt Symbol |
MOF, MYST1, ZC2HC8, hMOF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
K(lysine) acetyltransferase 8
|
| Other Description |
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1|MYST histone acetyltransferase 1|MYST-1|histone acetyltransferase KAT8|histone acetyltransferase MYST1|lysine acetyltransferase 8|ortholog of Drosophila males absent on the first (MOF)|probable histone acetyltransferase MYST1
|
| Swissprots |
Q9NR35 A8K4Z1 Q8WZ14 Q8WYB4 Q659G0 G5E9P2 Q8IY59 Q9H7Z6 Q9HAC5 Q7LC17
|
| Accessions |
EAW52157 EAW52158 Q9H7Z6 AA682878 AF217501 AAL56648 AF260665 AAF72665 AF289578 AAL55762 AK021872 BAB13924 AK024102 BAB14827 AK225660 AK291106 BAF83795 AL050395 CAH56416 BC037773 AAH37773 BP342476 CD364543 HG507946 XM_011545969 XP_011544271 XM_011545970 XP_011544272 XM_011545971 XP_011544273 NM_032188 NP_115564 NM_182958 NP_892003
|
| Function |
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. {ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:15923642, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10786633, ECO:0000269|PubMed:20018852}. Chromosome {ECO:0000250}.
|
