KAT8

Gene Symbol KAT8
Entrez Gene 84148
Alt Symbol MOF, MYST1, ZC2HC8, hMOF
Species Human
Gene Type protein-coding
Description K(lysine) acetyltransferase 8
Other Description MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1|MYST histone acetyltransferase 1|MYST-1|histone acetyltransferase KAT8|histone acetyltransferase MYST1|lysine acetyltransferase 8|ortholog of Drosophila males absent on the first (MOF)|probable histone acetyltransferase MYST1
Swissprots Q9NR35 A8K4Z1 Q8WZ14 Q8WYB4 Q659G0 G5E9P2 Q8IY59 Q9H7Z6 Q9HAC5 Q7LC17
Accessions EAW52157 EAW52158 Q9H7Z6 AA682878 AF217501 AAL56648 AF260665 AAF72665 AF289578 AAL55762 AK021872 BAB13924 AK024102 BAB14827 AK225660 AK291106 BAF83795 AL050395 CAH56416 BC037773 AAH37773 BP342476 CD364543 HG507946 XM_011545969 XP_011544271 XM_011545970 XP_011544272 XM_011545971 XP_011544273 NM_032188 NP_115564 NM_182958 NP_892003
Function Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. {ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:15923642, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10786633, ECO:0000269|PubMed:20018852}. Chromosome {ECO:0000250}.

MOF (G-12) - sc-271691 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MOF (G-12): sc-271691. Western blot analysis of MOF expression in non-transfected: sc-117752 (A) and mouse MOF transfected: sc-127160 (B) 293T whole cell lysates.

MOF (8C4C4) - sc-81163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MOF (8C4C4): sc-81163. Western blot analysis of MOF expression in HeLa (A), Caki-1 (B), COLO 320DM (C) and MCF7 (D) whole cell lysates.

MOF (T-20) - sc-13677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MOF (T-20): sc-13677. Western blot analysis of MOF expression in HeLa (A), SK-N-MC (B), Caki-1 (C), COLO 320DM (D), MCF7 (E) and Hep G2 (F) whole cell lysates.

MOF (T13H1B2) - sc-81765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MOF (T13H1B2): sc-81765. Western blot analysis of MOF expression in HeLa (A), Caki-1 (B), COLO 320DM (C) and MCF7 (D) whole cell lysates.

Anti-KAT8 / MYST1 / MOF antibody - ab83502 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KAT8 / MYST1 / MOF antibody (ab83502) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 4 : A498 (Human Kidney Carcinoma) Whole Cell Lysate Lane 5 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate Lane 6 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate Lane 7 : Caco 2 (Human colonic carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KAT8 / MYST1 / MOF antibody - ab72056 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling KAT8 / MYST1 / MOF with ab72056 at 1/1000 (1µg/ml). Detection: DAB.

Anti-KAT8 / MYST1 / MOF antibody - ab95145 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab95145, at 1/250 dilution, staining KAT8 / MYST1 / MOF in formalin-fixed, paraffin-embedded Human breast carcinoma by Immunohistochemistry using DAB detection. Epitope retrieval was performed.

Anti-KAT8 / MYST1 / MOF antibody [2603C2a] - ab71962 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2603C2a
Anti-KAT8 / MYST1 / MOF antibody [2603C2a] (ab71962) + immunising recombinant protein

Anti-KAT8 / MYST1 / MOF antibody [EPR15803] - ab200660 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15803
All lanes : Anti-KAT8 / MYST1 / MOF antibody [EPR15803] (ab200660) at 1/5000 dilutionLane 1 : HepG2 (Human liver hepatocellular carcinoma) whole cell lysateLane 2 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-KAT8 / MYST1 / MOF antibody [T13H1B2] - ab54276 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone T13H1B2
ab54276, staining MYST1/MOF in paraffin embedded human normal and tumour tissues by Immunohistochemistry. The primary antibody was diluted at 1/1000 dilution.

Anti-KAT8 / MYST1 / MOF antibody - C-terminal - ab71209 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KAT8 / MYST1 / MOF antibody - C-terminal (ab71209) at 1/60 dilution + K562 cell line lysate at 35 µg

Anti-KAT8 / MYST1 / MOF antibody - C-terminal - ab135071 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-KAT8 / MYST1 / MOF antibody - C-terminal (ab135071) at 1/1000 dilution (2hrs at RT) + K562 total cell extract

Anti-MYST1 Antibody - LS-C73109 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-MYST1 Antibody (C-Terminus) - LS-C73111 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYST1 Antibody (C-Terminus) - LS-C287824 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MYST1 Antibody (aa101-150) - LS-C199299 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using MYST1 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-MYST1 Antibody (N-Terminus) - LS-C107649 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MYST1 antibody LS-C107649 Western blot of THP-1 cell lysate.

Anti-MYST1 Antibody (aa409-439) - LS-C98657 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with HMOF/MYST1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-MYST1 Antibody (aa1-50) - LS-C286714 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MOF/MYST1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-MOF/MYST1 used at a dilution of 1:250. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.

Anti-MYST1 Antibody (aa120-480) - LS-C331988 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cell lines, using KAT8 antibody.

Anti-MYST1 Antibody - LS-C305934 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of MYST1 antibody LS-X223186.

Anti-MYST1 Antibody (clone 2603C2a) - LS-C184677 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2603C2a
Western blot of immunized recombinant protein using MYST1 antibody.

Anti-MYST1 Antibody - LS-C41496 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
IHC of paraffin-embedded human esophageal squamous cell carcinoma (A), normal esophagus epithelium (B), rectum adenocarcinoma (C), lung squamous cell carcinoma (D), breast infiltrating carcinoma (E), and breast infiltrat

Anti-MYST1 Antibody (clone 2603C2a) - LS-C342708 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2603C2a
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-MYST1 mAb.

Anti-MYST1 Antibody (aa100-150) - LS-C287825 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MOF/MYST1 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T and Jurkat cells. Antibodies: Affinity purified rabbit anti-MOF/MYST1 antibody used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
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