BCL2L1

Gene Symbol	BCL2L1
Entrez Gene	598
Alt Symbol	BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS
Species	Human
Gene Type	protein-coding
Description	BCL2-like 1
Other Description	apoptosis regulator Bcl-X|bcl-2-like protein 1|protein phosphatase 1, regulatory subunit 52
Swissprots	Q92976 Q5CZ89 Q5TE65 E1P5L6 Q07817
Accessions	AAB17354 BAA06406 CAT03369 CAT03400 CBX47501 CBX47502 EAW76424 EAW76425 EAW76426 EAW76427 EAW76428 EAW76429 Q07817 AK290968 BAF83657 AY263335 AAP22027 AY263336 AAP22028 AY263337 AAP22029 BC019307 AAH19307 BT007208 AAP35872 BX647525 CR936637 CAI56777 DQ893461 ABM84387 DQ896311 ABM87310 Z23115 CAA80661 Z23116 CAA80662 XM_005260486 XP_005260543 XM_005260487 XP_005260544 XM_011528960 XP_011527262 XM_011528961 XP_011527263 XM_011528962 XP_011527264 XM_011528963 XP_011527265 XM_011528964 XP_011527266 XM_011528965 XP_011527267 XM_011528966 XP_011527268 XR_936599 NM_001191 NP_001182 NM_138578 NP_612815
Function	Isoform Bcl-X(S) promotes apoptosis.
Subcellular Location	Isoform Bcl-X(L): Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.
Tissue Specificity	Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Top Pathways	Apoptosis, Toxoplasmosis, Pancreatic cancer, HTLV-I infection, Amyotrophic lateral sclerosis (ALS)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Bcl-xL siRNA I - 6362 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Bcl-xL siRNA II - 6363 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Bcl-x L siRNA (h) - sc-43630 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x L shRNA Plasmid (h) - sc-43630-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x L shRNA (h) Lentiviral Particles - sc-43630-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x siRNA (h) - sc-77361 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x shRNA Plasmid (h) - sc-77361-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x shRNA (h) Lentiviral Particles - sc-77361-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x S/L CRISPR/Cas9 KO Plasmid (h) - sc-400170 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L HDR Plasmid (h) - sc-400170-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L Double Nickase Plasmid (h) - sc-400170-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L Double Nickase Plasmid (h2) - sc-400170-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L CRISPR Activation Plasmid (h) - sc-400170-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L CRISPR Activation Plasmid (h2) - sc-400170-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L Lentiviral Activation Particles (h) - sc-400170-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L Lentiviral Activation Particles (h2) - sc-400170-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-x S/L siRNA (h) - sc-29216 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x S/L shRNA Plasmid (h) - sc-29216-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x S/L shRNA (h) Lentiviral Particles - sc-29216-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x s siRNA (h) - sc-37295 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x s shRNA Plasmid (h) - sc-37295-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x s shRNA (h) Lentiviral Particles - sc-37295-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x S/L siRNA (h2) - sc-44246 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x S/L shRNA Plasmid (h2) - sc-44246-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-x S/L shRNA (h2) Lentiviral Particles - sc-44246-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

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